TY - T1的抗原识别和避免在结果纤维化过敏性肺炎JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01336 -2021欧元六世- 60 - 4 SP - 2101336 AU - Tananchai Petnak AU - Charat Thongprayoon盟Misbah Baqir AU -杰伊·h·Ryu盟腾Moua Y1 - 2022/10/01 UR - //www.qdcxjkg.com/content/60/4/2101336.abstract N2 -背景可疑致病抗原可能是身份不明的30 - 50%的患者纤维化过敏性肺炎(f-HP)。目前尚不清楚抗原识别和避免在此设置提供任何额外的临床益处。我们假定的抗原识别和避免可能改善纤维化疾病患者的临床过程。方法患者会议最近国际惯例指导f-HP罗切斯特梅奥诊所诊断评估从2005年1月至2018年12月被包括在内。使役动词抗原和抗原回避明确定义并确定通过回顾医疗记录。Cox比例风险评估执行回归抗原识别和避免预测的全因死亡率或肺移植。结果377例患者包括在内。其中,怀疑病因抗原被发现在225年(60%)。疑似抗原的识别(调整风险比(人力资源)0.69,95%可信区间0.48 - -0.99;p = 0.04)和后续避免抗原(调整人力资源0.47,95%可信区间0.31 - -0.71;术;0.001)与降低全因死亡率和移植。 Both those with suspected antigen identification but nonavoidance and those with unidentifiable antigen had increased risk of all-cause mortality or transplantation (adjusted HR 2.22, 95% CI 1.34–3.69; p=0.002 versus adjusted HR 2.09, 95% CI 1.34–3.26; p=0.001, respectively). Exposure to avian antigen was associated with better outcome compared to other antigen subtypes (adjusted HR 0.63, 95% CI 0.43–0.93; p=0.02).Conclusion Our findings suggest that antigen identification and antigen avoidance remain relevant even in patients with fibrotic disease, where both appear to be associated with improved outcomes.Antigen identification and antigen avoidance appear to improve outcomes even in patients with fibrotic disease. Comprehensive ascertainment of causative antigen in fibrotic hypersensitivity pneumonitis should be encouraged in clinical practice. https://bit.ly/3ByUTy1 ER -