TY -的T1 -前吸烟暴露影响严重哮喘患者气道嗜酸性活化和自身免疫JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02446 -2021欧元六世- 60 - 4 SP - 2102446 AU - Ditte k . Klein AU -亚历山大Silberbrandt盟Laurits Frøssing Morten Hvidtfeldt盟盟- -安娜•冯•布劳盟Parameswaran Nair AU -这里离马纳利市穆克吉盟Celeste Porsbjerg Y1 - 2022/10/01 UR - //www.qdcxjkg.com/content/60/4/2102446.abstract N2 -介绍哮喘严重嗜酸性的特点是频繁的发作和类固醇的相对不敏感。气道嗜酸性实验、吸烟可能引起炎症反应,但严重哮喘患者的影响还不清楚。目的探讨之间的关系严重哮喘患者暴露于吸烟,气道嗜酸性炎症和激活,以及自身免疫和类固醇的响应能力。方法严重哮喘患者根据欧洲呼吸学会/美国胸科学会标准进行评估与痰液样本,分析细胞微分计算,和自由的存188bet官网地址在嗜酸性粒细胞颗粒(FEGs),嗜酸性粒细胞过氧化物酶(EPX)和巨噬细胞受体的自身抗体与胶原结构(MARCO)。气道嗜酸性亚组患者的炎症反应是2周后重新强的松。结果132严重哮喘患者被纳入研究。39例(29.5%)患者≥10久的吸烟史:36(27.3%)前吸烟者和三个(2.3%)吸烟者;和93年(70.5%)& lt; 10久的接触。嗜酸性气道炎症≥10久的患者中更为普遍(66.7%),而患者& lt; 10久(38.7%,p = 0.03),就像FEGs水平(p = 0.001) anti-EPX和anti-MARCO(术中,0.05和术中;0.0001,分别)。省略吸烟者没有影响这些关联。此外,强的松减少,但未恢复正常,患者的痰液嗜酸性粒细胞≥10 pack-year吸烟史。Conclusion In patients with severe asthma, a former smoking history is associated with eosinophilic airway inflammation and activation and relative insensitivity to steroids, as well as airway autoimmunity.In patients with severe asthma, former smoking exposure is associated with airway eosinophil activation and autoimmunity towards eosinophils and macrophages, as well as an incomplete anti-inflammatory response to systemic corticosteroids. https://bit.ly/3sTBJiF ER -