RT期刊文章SR电子T1临床、放射和病理结果后持续的肺病患者感染SARS-CoV-2摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2102411 10.1183/13993003.02411 -2021签证官60是4 A1克劳迪娅Ravaglia A1克劳迪奥Doglioni A1马可Chilosi A1莎拉Piciucchi A1亚历山德拉Dubini A1朱利奥罗西A1 Federica Pedic188bet官网地址a A1西尔维亚Puglisi A1卢卡Donati A1莎拉Tomassetti A1 Venerino Poletti年2022 UL //www.qdcxjkg.com/content/60/4/2102411.abstract AB的病人肺后遗症SARS-CoV-2感染后,从自限的异常主要的肺部疾病。肺组织形态学分析可以帮助我们理解致病机制,帮助提供一致的个性化管理。本研究的目的是确定肺组织的形态和immunomolecular特征。Transbronchial肺cryobiopsy在持续的症状和患者进行ct提示剩余肺病从SARS-CoV-2复苏后感染。164患者被怀疑肺COVID-19后后遗症;10 > 5%肺实质疾病患者进行肺活检。肺部疾病的组织模式是不均匀的,三种不同的情况下,集群可以被识别,这是通过他们的临床和放射学特征反映出来。集群1(“慢性fibrosing”)被感染后的预先存在的间质性肺炎为特征。集群2(“急性/亚急性损伤”)的特点是不同的类型和等级的肺损伤,从组织肺炎和fibrosing弥漫性肺泡损伤的非特异性间质性肺炎。集群3(“血管变化”)的特点是弥漫性血管增加,扩张和变形(毛细血管和小静脉)在其他正常的实质。 Clusters 2 and 3 had immunophenotypical changes similar to those observed in early/mild COVID-19 pneumonias (abnormal expression of STAT3 in hyperplastic pneumocytes and PD-L1, IDO and STAT3 in endothelial cells). This is the first study correlating histological/immunohistochemical patterns with clinical and radiological pictures of patients with post-COVID lung disease. Different phenotypes with potentially different underlying pathogenic mechanisms have been identified.Post-COVID lung disease is not a single entity, but includes different subtypes, each of them potentially requiring separate and different management https://bit.ly/3BJDeUF