188bet官网地址RT Journal Article SR Electronic T1 Using chest computed tomography and unsupervised machine learning for predicting and evaluating response to lumacaftor–ivacaftor in people with cystic fibrosis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 2101344 DO 10.1183/13993003.01344-2021 VO 59 IS 6 A1 Campredon, Alienor A1 Battistella, Enzo A1 Martin, Clémence A1 Durieu, Isabelle A1 Mely, Laurent A1 Marguet, Christophe A1 Belleguic, Chantal A1 Murris-Espin, Marlène A1 Chiron, Raphaël A1 Fanton, Annlyse A1 Bui, Stéphanie A1 Reynaud-Gaubert, Martine A1 Reix, Philippe A1 Hoang-Thi, Trieu-Nghi A1 Vakalopoulou, Maria A1 Revel, Marie-Pierre A1 Da Silva, Jennifer A1 Burgel, Pierre-Régis A1 Chassagnon, Guillaume A1 A1 , A1 Mounard, Julie A1 Poulet, Claire A1 Rames (Amiens), Cinthia A1 Person, Christine A1 Troussier, Françoise A1 Urban (Angers), Thierry A1 Dalphin, Marie-Laure A1 Dalphin, Jean-Claude A1 Pernet, Didier A1 Richaud-Thiriez (Besançon), Bénédicte A1 Bui, Stéphanie A1 Fayon, Mickael A1 Macey-Caro (Bordeaux), Julie A1 Campbell, Karine A1 Laurans (Caen), Muriel A1 Borderon, Corinne A1 Heraud, Marie-Christine A1 Labbé, André A1 Montcouquiol (Clermont-Ferrand), Sylvie A1 Bassinet, Laurence A1 Remus (Créteil), Natascha A1 Fanton, Annlyse A1 Houzel-Charavel, Anne A1 Huet, Frédéric A1 Perez-Martin (Dijon), Stéphanie A1 Boldron-Ghaddar, Amale A1 Scalbert (Dunkerque), Manuela A1 Mely (Giens), Laurent A1 Camara, Boubou A1 Llerena, Catherine A1 Pin, Isabelle A1 Quétant (Grenoble), Sébastien A1 Cottereau, Aurélie A1 Deschildre, Antoine A1 Gicquello, Alice A1 Perez, Thierry A1 Stervinou-Wemeau, Lidwine A1 Thumerelle, Caroline A1 Wallaert, Benoit A1 Wizla (Lille), Nathalie A1 Languepin, Jane A1 Ménétrey, Céline A1 Dupuy-Grasset (Limoges), Magalie A1 Bazus, Lucie A1 Buchs, Clelia A1 Jubin, Virginie A1 Werck-Gallois, Marie-Christine A1 Mainguy, Catherine A1 Perrin, Thomas A1 Reix, Philippe A1 Toutain-Rigolet (Lyon Pédiatrie), Agnès A1 Durieu, Isabelle A1 Durupt, Stéphane A1 Reynaud, Quitterie A1 Nove-Josserand (Lyon adultes), Raphaele A1 Baravalle-Einaudi, Melisande A1 Coltey, Bérangère A1 Dufeu, Nadine A1 Dubus, Jean-Christophe A1 Stremler (Marseille), Nathalie A1 Caimmi, Davide A1 Chiron (Montpellier), Raphaël A1 Billon, Yves A1 Derelle, Jocelyne A1 Kieffer, Sébastien A1 Pichon, Anne-Sophie A1 Schweitzer, Cyril A1 Tatopoulos (Nancy), Aurélie A1 Abbes, Sarah A1 Bihouée, Tiphaine A1 Danner-Boucher, Isabelle A1 David, Valérie A1 Haloun, Alain A1 Tissot (Nantes), Adrien A1 Leroy, Sylvie A1 Bailly-Piccini (Nice), Carole A1 Clément, Annick A1 Corvol, Harriet A1 Tamalet (ParisTrousseau), Aline A1 Burgel, Pierre-Régis A1 Honoré, Isabelle A1 Hubert, Dominique A1 Kanaan, Reem A1 Martin (Paris Cochin), Clémence A1 Bailly, Cécile A1 Chédevergne, Frédérique A1 De Blic, Jacques A1 Fauroux, Brigitte A1 Bourgeois, Murielle Le A1 Sermet-Gaudelus (Paris Necker), Isabelle A1 Delaisi, Bertrand A1 Gérardin, Michèle A1 Munck (ParisRobert Debré), Anne A1 Abély, Michel A1 Ravoninjatovo (Reims), Bruno A1 Belleguic, Chantal A1 Desrues, Benoit A1 Brinchault (Rennes), Graziella A1 Dagorne, Michel A1 Deneuville, Eric A1 Lefeuvre (Rennes-Saint Brieuc), Sylvaine A1 Dirou, Anne A1 Bihan, Jean Le A1 Ramel (Roscoff), Sophie A1 Dominique, Stéphane A1 Marguet (Rouen), Christophe A1 Payet (La Réunion), Annabelle A1 Kessler, Romain A1 Porzio, Michele A1 Rosner, Vincent A1 Weiss (Strasbourg), Laurence A1 Miranda, Sandra de A1 Grenet, Dominique A1 Hamid, Abdoul A1 Picard (Suresnes), Clément A1 Brémont, François A1 Didier, Alain A1 Labouret, Géraldine A1 Mittaine, Marie A1 Murris-Espin, Marlène A1 Têtu (Toulouse), Laurent A1 Cosson, Laure A1 Giraut, Charlotte A1 Henriet, Anne-Cécile A1 Mankikian, Julie A1 Marchand (Tours), Sophie A1 Hugé, Sandrine A1 Storni (Vannes), Véronique A1 Coirier-Duet (Versailles), Emmanuelle YR 2022 UL //www.qdcxjkg.com/content/59/6/2101344.abstract AB Objectives Lumacaftor–ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator known to improve clinical status in people with cystic fibrosis (CF).研究的目的是评估一年lumacftor-ivacftor处理后肺结构变化,并使用不受监督机学习识别与响应lumacftor-ivacftor相联的肺病形态型CT扫描使用修改版Bhalla评分k均值聚类法基于120个放射性特征从非增强前胸部CT扫描中提取百拉分数在lmacftor-ivacftor一年后显著下降(-1.40+1.53分比前CCTp<0.001)。发现与微积分大幅下降相关联(-0.58+0.88点,p<0.001),支气管墙厚化(-0.35+0.62点,p<0.001)和近距离整合(-0.24+0.52点,p<0.001)。集群分析识别三大形态集群C集群病人比其他集群病人更有可能经历百分率预测强制破解容量增加1ss(FEV1%预设值)+5%与lmacftor-ivacftor相连接的一年治疗与胸口CT支气管疾病显著改善相联处理前CT扫描放射性特征可能有助于预测肺功能响应CT扫描可帮助识别Lumacaftor-ivacftor下肺功能改善概率较高的病人https://bit.ly/3FUrUXv