TY - T1的药物暴露和易感性的二线药物与耐多药结核病患者的治疗反应:一项多中心前瞻性队列研究在中国摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.01925 -2021欧元六世- 59 - 3 SP - 2101925 AU - Xubin郑AU -戴维斯莉娜Forsman声称通过非盟紫薇朱宁宝盟-谢燕盟盟-托马斯•绍恩盟Judith Bruchfeld AU -完徐盟Jan-Willem Alffenaar AU - Yi胡锦涛Y1 2022/03/01 UR - //www.qdcxjkg.com/content/59/3/2101925.abstract N2 -背景理解药物暴露和易感性的影响治疗耐多药结核病(mdr - tb)的反应将有助于优化治疗。本研究旨在探讨药物之间的关系曝光,敏感性和应对耐多药结核病治疗。方法药物暴露和二线药物敏感性测定耐多药结核病患者。多变量分析应用研究药物暴露和易感性的影响对痰文化转换和治疗结果。目标实现的概率评估。随机森林和购物车(分类和回归树)分析用来确定关键指标及其临床目标患者在世界卫生组织推荐的方案。结果药物暴露和相应的敏感性为197耐多药结核病患者提供了可能。目标实现的概率是高度可变的,从linezolid乙胺丁醇为0%至97%,而患者氟喹诺酮类原料药目标上空有较高的概率两个文化转换(分别为56.3%和28.6%;调整或2.91,95% CI 1.42 - -5.94)和有利的结果(分别为88.8%和68.8%;调整或2.89,95%可信区间1.16 - -7.17)。氟喹诺酮类原料药的曝光值更高,linezolid和吡嗪酰胺与早些时候有关痰文化转换。车分析选定的莫西沙星药物浓度时间曲线下面积/的最小抑制浓度(AUC0-24h /麦克风)231和linezolid AUC0-24h /麦克风287最佳预测6个月文化转换的患者接受相同的组本文方案。 These associations were confirmed in multivariate analysis.Conclusions Our findings indicate that target attainment of TB drugs is associated with response to treatment. The CART-derived thresholds may serve as targets for early dose adjustment in a future randomised controlled study to improve MDR-TB treatment outcome.Drug exposure and susceptibility were proved to be associated with treatment responses during multidrug-resistant tuberculosis treatment, and identified thresholds may serve as targets for dose adjustment in future clinical studies to improve treatment efficacy https://bit.ly/3pZQbFU ER -