2017-2019年法国因呼吸道合胞病毒感染住院的成人住院和中期出院后并发症:JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 2100651 DO 10.1183/13993003.00651-2021 188bet官网地址VO 59 IS 3 A1 Descamps, Alexandre A1 Lenzi, Nezha A1 Galtier, Florence A1 Lainé， Fabrice A1 Lesieur, Zineb A1 Vanhems, Philippe A1 Amour, Sélilah A1 L’honneur, Anne-Sophie A1 Fidouh, Nadhira A1 Foulongne, Vincent A1 Lagathu, Gisèle A1 Duval, Xavier A1 Merle, Corinne A1 Lina, Bruno A1 Carrat, Fabrice A1 Launay, Odile A1 Loubet, Paul A1，本研究的目的是描述因流感样疾病(ILI)住院的成人呼吸道合胞病毒(RSV)感染的临床特征和住院和出院后的结局，并与因流感住院的患者进行比较。方法前瞻性地纳入连续两个冬季(2017/2018和2018/2019)在法国五所大学医院住院的患有ILI的成年人。采用多重反转录PCR方法检测鼻咽拭子呼吸道合胞病毒和流感病毒。将rsv阳性患者与rsv阴性和流感阳性住院患者进行比较。泊松回归模型用于估计RSV和流感感染之间与住院和出院后结果相关的调整流行率(aPR)。住院结局是至少一种并发症的发生、住院时间≥7天、入住重症监护病房、使用机械通气和住院死亡的综合。出院后结局包括30和90天全因死亡率和90天再入院率。总的来说，1428名住院的成年ILI患者被纳入研究。8%(1428例中114例)检测到RSV, 31%(1428例中437例)检测到流感病毒。呼吸道合胞病毒住院患者比流感患者年龄更大(平均年龄73.0岁对68.8岁，p=0.015)，患慢性呼吸系统或心脏疾病的频率更高(52%对39%，p=0.012, 52%对41%，p=0.039)，住院时间更长(中位住院时间8天对6天，p<0.001)。 Anti-influenza therapies were less prescribed among RSV patients than influenza patients (20% versus 66%, p<0.001). In-hospital composite outcome was poorer in RSV patients (aPR 1.5, 95% CI 1.1–2.1) than in those hospitalised with influenza. No difference was observed for the post-discharge composite outcome (aPR 1.1, 95% CI 0.8–1.6).Conclusion RSV infection results in serious respiratory illness, with worse in-hospital outcomes than influenza and with similar midterm post-discharge outcomes.Respiratory syncytial virus infection in hospitalised adults with influenza-like illness was associated with poor in-hospital and midterm post-discharge outcomes, which may be worse than or similar to those of patients with influenza virus infection https://bit.ly/2VAsMhh