@article {Weckmann2003969作者={马库斯Weckmann和托马斯Bahmer Jannie玛丽沙和莎拉·R {\ o} nnow和马丁Pech Cornelis Vermeulen和阿伦的费和戴安娜朱莉Leeming Morten阿塞Karsdal和Lars隆德和布莱恩·乔治·g·奥利弗和迈克尔Wegmann古娟Ulrich-Merzenich和乌维R . Juergens Jannis Duhn Yves Laumonnier和Olga Danov凯瑟丽娜Sewald和乌尔里希Zissler Marnix Jonker Inke K {\ " o}国家Gesine汉森和埃里卡von Mutius奥利弗·福克斯和安娜>玛利亚比安卡肖布Christine Happle和克劳斯·f·瑞芭Maarten van de Berge和简妮特凯伯吉斯和马提亚科普下},编辑= {},title = {COL4A3退化在过敏性哮喘和退化预测响应ige疗法},体积= {58}= {6},elocation-id = {2003969} = {2021}, doi ={10.1183/13993003.03969 -2020},出版商={欧洲呼吸学会},文摘={背景哮喘是一种异构综合征充实endotype-specific生物标志物的迫切要求。188bet官网地址Dysbalance哮喘肺组织的纤维化和fibrolysis导致减少的水平inflammation-protective胶原蛋白4 (COL4A3)。目的描述退化COL4A3过敏性气道炎症和评估合成产品作为ige疗法反应的生物标记。方法血清学标记C4Ma3 COL4A3退化(丹麦北欧生物科学)和血清细胞因子测定联盟群(儿科病例/控制:n = 134 / n = 35;成人病例/控制:n = 149 / n = 31)。小鼠过敏性气道疾病的恶化是由感光卵白蛋白(OVA),挑战与卵子气溶胶和滴剂的聚(cytidylic-inosinic)。Fulacimstat (chymase抑制剂;拜耳)是用来确定肥大细胞的作用chymase COL4A3退化。囊性纤维化患者(n = 14)和囊性纤维化过敏性支气管肺的曲霉病(ABPA;n = 9)以及严重的过敏不受控制的哮喘患者(n = 19)检测COL4A3退化。 Omalizumab (anti-IgE) treatment was assessed using the Asthma Control Test.Results Serum levels of C4Ma3 were increased in asthma in adults and children alike and linked to a more severe, exacerbating allergic asthma phenotype. In an experimental asthma mouse model, C4Ma3 was dependent on mast cell chymase. Serum C4Ma3 was significantly elevated in cystic fibrosis plus ABPA and at baseline predicted the success of the anti-IgE therapy in allergic, uncontrolled asthmatics (diagnostic OR 31.5).Conclusion C4Ma3 levels depend on lung mast cell chymase and are increased in a severe, exacerbating allergic asthma phenotype. C4Ma3 may serve as a novel biomarker to predict anti-IgE therapy response.A novel, serological biomarker predicts the anti-IgE therapy response in asthmatics. The neo-epitope biomarker C4Ma3 measures the increase of lung collagen 4 degradation in severe exacerbating type 2 asthma and depends on mast cell chymase activity. https://bit.ly/3ejFp7i}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/6/2003969}, eprint = {//www.qdcxjkg.com/content/58/6/2003969.full.pdf}, journal = {European Respiratory Journal} }