RT期刊文章SR电子T1肾素 - 血管紧张素系统与慢性肺同种异体移植功能障碍JF欧洲呼吸杂志188bet官网地址A1 Mohammed-Ali，Zahraa A1 Kotlyar，Max A1 Levy，Liran A1 Clotet-Freixas，Sergi A1 Ly，Phillip A1 Renaud-Picard，Benjamin a1 Zehong，Guan A1 Zehong，Guan A1 Daigneaeault，Tina A1 Duong，Tina A1 Duong，Allen A1 Batruch，Allen A1 Batruch，Ihor a1 Yhor A1 Yhor A111，A1 KONVALINKA，ANA A1 MARTINU，TEREZA YR 2021 UL //www.qdcxjkg.com/content/58/4/4/2002975.ABSTRACT AB慢性肺同种异体同种异体同种异体同种异体同种异体功能障碍（CLAD）是死亡后死亡的主要原因。血管紧张素II（AngII）是肾素 - 血管紧张素系统的主要效应子，在肾脏和肺中引起纤维化。我们鉴定了六种血管蛋白（RAS同源性家族成员B（RHOB），骨髓基质细胞抗原1（BST1），溶血磷脂酶1（LYPA1）（LYPA1），谷氨酰胺合成酶（GLNA），血小板福音蛋白1（TSP1）（TSP1）和laminin subunitβ2（Lambunitβ2）））肾脏同种异体纤维化患者尿液中增加的。我们假设肾素 - 血管紧张素系统在外壳中活跃，并且在支气管肺泡灌洗液（BAL）中增加了血管杆菌调节的蛋白。我们对10个clad Lungs的Angii受体（AGTR1和AGTR2）进行免疫染色（AGTR1和AGTR2），TSP1和GLNA和五个控件。使用质谱法，我们对40个肺移植受体（稳定，急性肺同种异体功能障碍（ALAD）和CLAD）的BAL中对应于Angii调节蛋白的肽进行了定量。开发机器学习算法是为了根据BAL肽浓度预测外壳。免疫染色在外壳与对照肺中的AGTR1+细胞明显更多（P = 0.02）。TSP1和GLNA免疫染色与肺纤维化程度正相关（分别为R2 = 0.42和0.57）。 In BAL, we noted a trend towards higher concentrations of AngII-regulated peptides in patients with CLAD at the time of bronchoscopy, and significantly higher concentrations of BST1, GLNA and RHOB peptides in patients that developed CLAD at follow-up (p<0.05). The support vector machine classifier discriminated CLAD from stable and ALAD patients at the time of bronchoscopy (area under the curve (AUC) 0.86) and accurately predicted subsequent CLAD development (AUC 0.97).Proteins involved in the renin–angiotensin system are increased in CLAD lungs and BAL. AngII-regulated peptides measured in BAL may accurately identify patients with CLAD and predict subsequent CLAD development.Components of the renin–angiotensin system are increased in chronic lung allograft dysfunction (CLAD) fibrosis. Angiotensin II-regulated proteins in bronchoalveolar lavage identify concurrent and predict future CLAD in lung transplant recipients. https://bit.ly/3eRYez7