RT期刊文章SR电子T1 Multi-omics链接白介素trans-signalling与中性粒细胞胞外形成和陷阱嗜血杆菌感染在慢性阻塞性肺病摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2003312 10.1183/13993003.03312 188bet官网地址-2020签证官58是4 A1索非亚温斯洛A1莉娜Odqvist A1莎拉潜水员A1丽贝卡·里瑟A1 Suado Abdillahi A1塞西莉亚Wingren A1海伦娜Lindmark A1安妮卡2亩A1索非亚必A1琳达Yrlid A1伊丽莎白Ax A1姆久卡诺维奇A1斯bloom A1安德鲁·海厄姆A1戴夫·辛格A1托马斯Southworth A1克里斯托弗·e·Brightling A1 Henric k·奥尔森A1硼砂Jevnikar年2021 UL //www.qdcxjkg.com/content/58/4/2003312.abstract AB背景:白介素(IL) 6 trans-signalling (IL-6TS)正成为一个在慢性呼吸道疾病发病机理;然而,司机的IL-6TS航空和增加患者的表型特征IL-6TS途径激活仍然知之甚少。目的:我们的目的是识别和描述慢性阻塞性肺病患者增加气道IL-6TS并阐明生物司机IL-6TS途径激活。方法:我们使用了一个IL-6TS-specific痰生物标志物概要(可溶性白介素受体(sIL-6R)、il - 6, IL-1β,引发,巨噬细胞炎性protein-1β)从COPD患者痰分层数据(n = 74;生物标记目标抗生素和系统性皮质类固醇治疗COPD恶化(BEAT-COPD))通过分层聚类。IL-6TS签名与临床特点和唾液微生物组配置文件。中性粒细胞胞外陷阱形成的感应(NETosis)和IL-6TS流感嗜血杆菌进行了研究在人类中性粒细胞。结果:分层聚类显示IL-6TS-high子集(n = 24)慢性阻塞性肺病的患者,与一个共同的表型性状IL-6TS-high子集之前发现哮喘。子集的特征是增加痰细胞计数(p = 0.0001),持续的痰液嗜中性(p = 0.0004),减少生活质量(慢性呼吸道问卷总分;p = 0.008),提高水平的促炎介质和基质金属蛋白酶的痰。 IL-6TS-high COPD patients showed an increase in Proteobacteria, with Haemophilus as the dominating genus. NETosis induced by H. influenzae was identified as a potential mechanism for increased sIL-6R levels. This was supported by a significant positive correlation between sIL-6R and NETosis markers in bronchoalveolar lavage fluid from COPD patients.Conclusion: IL-6TS pathway activation due to chronic colonisation with Haemophilus may be an important disease driver in a subset of COPD patients.Lung IL-6 trans-signalling driven by Haemophilus influenzae-induced NETosis is a pathological feature of COPD patients with chronic Haemophilus infection, stable neutrophilic inflammation and uncontrolled disease https://bit.ly/30vhgD5