TY -的T1 Multi-omics链接IL - 6与中性粒细胞胞外trans-signalling陷阱形成和< em >嗜血杆菌< / em >感染在慢性阻塞性肺病JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.03312 -2020欧元六世- 58 - 4 SP - 2003312 AU -索菲亚·温斯洛盟莉娜Odqvist AU -萨拉潜水员盟-丽贝卡·里瑟盟Suado Abdillahi AU -塞西莉亚Wingren AU -海伦娜Lindmark盟-安妮卡2亩AU -索菲亚Lundin盟琳达Yrlid AU -伊丽莎白Ax盟-姆也有非盟-斯bloom AU -安德鲁·海盟-戴夫·辛格盟-托马斯Southworth AU -克里斯托弗·e·Brightling盟Henric k·奥尔森AU -硼砂Jevnikar Y1 - 2021/10/01 UR - //www.qdcxjkg.com/content/58/4/2003312.abstract N2 -背景:白介素(IL) 6 trans-signalling (IL-6TS)正成为一个在慢性呼吸道疾病发病机理;然而,司机的IL-6TS航空和增加患者的表型特征IL-6TS途径激活仍然知之甚少。目的:我们的目的是识别和描述慢性阻塞性肺病患者增加气道IL-6TS并阐明生物司机IL-6TS途径激活。方法:我们使用了一个IL-6TS-specific痰生物标志物概要(可溶性白介素受体(sIL-6R)、il - 6, IL-1β,引发,巨噬细胞炎性protein-1β)从COPD患者痰分层数据(n = 74;生物标记目标抗生素和系统性皮质类固醇治疗COPD恶化(BEAT-COPD))通过分层聚类。IL-6TS签名与临床特点和唾液微生物组配置文件。中性粒细胞胞外陷阱形成的感应(NETosis)和IL-6TS流感嗜血杆菌进行了研究在人类中性粒细胞。结果:分层聚类显示IL-6TS-high子集(n = 24)慢性阻塞性肺病的患者,与一个共同的表型性状IL-6TS-high子集之前发现哮喘。子集的特征是增加痰细胞计数(p = 0.0001),持续的痰液嗜中性(p = 0.0004),减少生活质量(慢性呼吸道问卷总分;p = 0.008),提高水平的促炎介质和基质金属蛋白酶的痰。 IL-6TS-high COPD patients showed an increase in Proteobacteria, with Haemophilus as the dominating genus. NETosis induced by H. influenzae was identified as a potential mechanism for increased sIL-6R levels. This was supported by a significant positive correlation between sIL-6R and NETosis markers in bronchoalveolar lavage fluid from COPD patients.Conclusion: IL-6TS pathway activation due to chronic colonisation with Haemophilus may be an important disease driver in a subset of COPD patients.Lung IL-6 trans-signalling driven by Haemophilus influenzae-induced NETosis is a pathological feature of COPD patients with chronic Haemophilus infection, stable neutrophilic inflammation and uncontrolled disease https://bit.ly/30vhgD5 ER -