@article {Winslow2003312作者={索非亚温斯洛和莉娜Odqvist莎拉潜水员和丽贝卡·里瑟Suado Abdillahi和塞西莉亚Wingren海伦娜Lindmark和安妮卡2亩索非亚必和琳达Yrlid伊丽莎白Ax和姆也有斯bloom和安德鲁·海厄姆和戴夫·辛格和托马斯·Southworth和克里斯托弗·e·Brightling Henric k·奥尔森和硼砂Jevnikar}, title = {Multi-omics链接IL - 6与中性粒细胞胞外trans-signalling陷阱形成和嗜血杆菌感染在慢性阻塞性肺病},体积= {58}= {4},elocation-id = {2003312} = {2021}, doi ={10.1183/13993003.03312 -2020},出版商={欧洲呼吸学会},文摘={背景:白介素(IL) 6 trans-signalling (IL-6TS)正成为一个在慢性呼吸道疾病发病机理;188bet官网地址然而,司机的IL-6TS航空和增加患者的表型特征IL-6TS途径激活仍然知之甚少。目的:我们的目的是识别和描述慢性阻塞性肺病患者增加气道IL-6TS并阐明生物司机IL-6TS途径激活。方法:我们使用了一个IL-6TS-specific痰生物标志物概要(可溶性白介素受体(sIL-6R)、il - 6, IL-1β,引发,巨噬细胞炎性protein-1β)从COPD患者痰分层数据(n = 74;生物标记目标抗生素和系统性皮质类固醇治疗COPD恶化(BEAT-COPD))通过分层聚类。IL-6TS签名与临床特点和唾液微生物组配置文件。中性粒细胞胞外陷阱形成的感应(NETosis)和IL-6TS流感嗜血杆菌进行了研究在人类中性粒细胞。结果:分层聚类显示IL-6TS-high子集(n = 24)慢性阻塞性肺病的患者,与一个共同的表型性状IL-6TS-high子集之前发现哮喘。子集的特征是增加痰细胞计数(p = 0.0001),持续的痰液嗜中性(p = 0.0004),减少生活质量(慢性呼吸道问卷总分;p = 0.008),提高水平的促炎介质和基质金属蛋白酶的痰。 IL-6TS-high COPD patients showed an increase in Proteobacteria, with Haemophilus as the dominating genus. NETosis induced by H. influenzae was identified as a potential mechanism for increased sIL-6R levels. This was supported by a significant positive correlation between sIL-6R and NETosis markers in bronchoalveolar lavage fluid from COPD patients.Conclusion: IL-6TS pathway activation due to chronic colonisation with Haemophilus may be an important disease driver in a subset of COPD patients.Lung IL-6 trans-signalling driven by Haemophilus influenzae-induced NETosis is a pathological feature of COPD patients with chronic Haemophilus infection, stable neutrophilic inflammation and uncontrolled disease https://bit.ly/30vhgD5}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/4/2003312}, eprint = {//www.qdcxjkg.com/content/58/4/2003312.full.pdf}, journal = {European Respiratory Journal} }