RT Journal文章SR电子T1对阻塞性睡眠呼吸暂停的影响和间歇性缺氧对血液流变学：翻译学习JF欧洲呼吸期刊Jo Eur Respir J FD欧洲呼吸学会SP 2100352 Do 10.1183 / 13993003.00352-2021 VO 58是4 A1 Waltz，Xavier A1188bet官网地址Beaudin，Andrew E. A1 Belaidi，Elise A1 Raneri，Jiill A1Pépin，Jean-Louis A1 Pialoux，Vincent A1 Hanly，Patrick J. A1 Verges，Samuel A1 Poulin，Marc J. YR 2021 UL http：//erj.ersjourt http：//erj.ersjourth。COM / CONTER / 58/4 / 2100352.Abstract AB背景在阻塞性睡眠呼吸暂停（OSA）中报告了血管色改变，并以连续的正气道压力（CPAP）反转，观察可能由间歇性缺氧（IH）引起的氧化应激。我们的目的是探讨IH是否通过氧化应激导致血管干燥改变。方法将Wistar大鼠暴露于常氧（n = 7）或Ih（n = 8）14天。23中度至严重的OSA患者在三个时间点进行评估：基线，在随机化到夜行氧（n = 13）的2周或没有治疗（n = 10）和1个月的CPAP处理后（n =17）。此外，在基线和时间匹配后续后评估OSA的对照组（n = 13）。我们测得血管系参数（血细胞比容，血液粘度，血浆粘度（大鼠），红细胞聚集和可变形性（仅限）和氧化还原平衡（超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶，蛋白质氧化（晚期氧化蛋白质产品（AOPPS））和脂质过氧化（丙二醛））。我们还使用氧化剂叔丁基氢过氧化物（TBHP）在大鼠中，在我们的人体参与者中测试红细胞对反应性氧物种（ROS）的血管生态学敏感性。大鼠，IH通过增加血细胞比容而不改变红细胞的血管色特性增加血液粘度。IH也减少了SOD活性和增加的AOPP。 In humans, baseline haemorheological properties were similar between patients and control participants, and properties were unaltered following oxygen and CPAP, except erythrocyte deformability was reduced following oxygen therapy. Redox balance was comparable between patients and control participants. At baseline, TBHP induced a greater reduction of erythrocyte deformability in patients while CPAP reduced TBHP-induced increase in aggregation strength.Conclusions IH and OSA per se do not cause haemorheological alterations despite the presence of oxidative stress or higher sensitivity to ROS, respectively.Obstructive sleep apnoea and/or intermittent hypoxia per se are not significantly implicated in haemorheological disturbances https://bit.ly/3seciGd