RT期刊文章SR电子T1血液嗜酸性粒细胞计数和阻塞性肺疾病的发展：Kangbuk Samsung Health研究JF欧洲呼吸系统杂志JO EUR RESSIR J FD欧洲呼吸学会SP 2003823 DO 10.1183/139993003.033003.033823-2020 VO 58188bet官网地址Yun A1 Chang，Yoosoo A1 Kang，Danbee A1 Hong，Yun Soo A1 Zhao，di A1 Ahn，Jiin A1 Shin，Sun Hye A1 Singh，Dave A1 Guallar，Eliseo A1 Cho，Juhee A1 Ryu，Seungho yr 2021 ul Http：yr 2021 ul Http：// http：//www.qdcxjkg.com/content/58/4/4/2003823.ABSTRACT AB的目标是血液嗜酸性粒细胞对慢性阻塞性肺病（COPD）发展的影响是未知的。我们调查了较高的血液嗜酸性粒细胞计数是否与在基线上有肺部无肺疾病的大量男性和女性中患有阻塞性肺疾病（旧）的风险有关。方法是对359 456个没有历史的韩国成年人的队列研究哮喘和基线时没有老年人，他们参加了包括肺活量测定法在内的健康筛查检查。旧被定义为1 s（FEV1）/强制生命力（FVC）<0.7 <0.7和FEV1 <80％预测的前支支气管扩展器强迫呼气体积。 years, 5008 participants developed incident OLD (incidence rate 2.1 (95% CI 2.1–2.2) per 1000 person-years). In the fully adjusted model, the hazard ratios for incident OLD comparing eosinophil counts of 100– <200, 200– <300, 300– <500 and ≥500 versus <100 cells·μL−1 were 1.07 (95% CI 1.00–1.15), 1.30 (95% CI 1.20–1.42), 1.46 (95% CI 1.33–1.60) and 1.72 (95% CI 1.51–1.95), respectively (ptrend<0.001). These associations were consistent in clinically relevant subgroups, including never-, ex- and current smokers.Conclusion In this large longitudinal cohort study, blood eosinophil counts were positively associated with the risk of developing of OLD. Our findings indicate a potential role of the eosinophil count as an independent risk factor for developing COPD.Blood eosinophil counts were positively associated with the risk of developing obstructive lung disease in a large longitudinal cohort of young and middle-aged men and women https://bit.ly/37QeCeW