TY -的T1 -一种干扰素诱导的气道疾病从血液基因表达分析JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00569 -2021欧元SP - 2100569 AU - Yun,宋h . AU -李,唆使盟,Srinivasa Pooja盟——明天,Jarrett盟——追逐,罗伯特•AU - Saferali Aadbida盟——徐,辉AU - Cho,迈克尔•AU -卡斯塔尔迪彼得AU -赫斯,克雷格·p·Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/09/29/13993003.00569 - 2021. -抽象N2 -背景的分子基础在慢性阻塞性肺疾病气道重塑仍然知之甚少。我们确定了基因表达特征与胸部CT扫描气道相关措施理解分子途径与呼吸道疾病有关。方法在2396例COPDGene研究中,我们调查了定量CT气道表型之间的关系和血液转录组识别气道疾病特性基因和定义一个气道壁厚(AWT)基因组得分。多变量回归分析确定关联的AWT得分与临床表型,支气管基因表达和基因变异。结果1型干扰素诱导的基因都与气道壁厚有关,Pi10,和墙面积百分比,最强的浓缩气道壁厚。得分来自18个基因的表达与AWT与COPD-related表型包括减少肺功能(FEV1%−3.4,预测术;0.05)和增加急性加重(术中发病率比1.6;0.05)。AWT得分是人工繁殖与支气管气道壁厚样本来自23个学科(3.22测试版,术中;0.05)。血液AWT分数与基因变异rs876039有关,一种表达数量性状位点(eQTL) IKZF1的基因调节干扰素信号和与炎症相关疾病。结论从外周血基因表达与干扰素刺激基因签名和支气管刷与CT气道壁厚有关,肺功能和加重。共享基因和基因关联显示病毒反应和/或自身免疫失调的潜在潜在机制在COPD气道疾病。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。 After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Yun reports grants from National Institutes of Health, during the conduct of the study; grants from Bayer, outside the submitted work; .Conflict of interest: Dr. Lee has nothing to disclose.Conflict of interest: Dr. Srinivasa has nothing to disclose.Conflict of interest: Dr. Morrow reports grants from National Institutes of Health, during the conduct of the study; .Conflict of interest: Mr. Chase has nothing to disclose.Conflict of interest: Dr. Saferali has nothing to disclose.Conflict of interest: Dr. Xu has nothing to disclose.Conflict of interest: Dr. Cho reports personal fees from Genentech, personal fees from AstraZeneca, personal fees from Illumina, grants from Bayer, grants from GSK, outside the submitted work; .Conflict of interest: Dr. Castaldi reports personal fees from GSK, grants from GSK, personal fees from Novartis, outside the submitted work; .Conflict of interest: Dr. Hersh reports grants from NHLBI, during the conduct of the study; grants from Boehringer-Ingelheim, grants from Novartis, personal fees from 23andMe, outside the submitted work; . ER -