% 0期刊文章%艾玛Satrell %一个海格Clemm %一个Ola Røksund %卡尔Ove Hufthammer %艾纳于%玛丽亚Vollsæter托马斯Halvorsen % % T发展肺扩散到成年后极度早产2021% % D J R 10.1183/13993003.04103 -2020%欧洲呼吸杂志% P 2004103 % X背景气体交换在极早产(EP)婴儿必须发生在胎儿肺。儿童肺一氧化碳扩散能力(DLCO)减少;然而,纵向发展尚未研究。我们描述的增长DLCO及其子组件到成年EP-born相比term-born科目。方法两组成立出生胎龄≤28周或出生体重≤1000克1982 - 1985年(n = 48)和1991 - 1992 (n = 35)检查两次,18 - 25岁,10岁和18岁,分别比匹配term-born控制。在两次呼吸DLCO测量氧气压力,与子组件(膜扩散(DM)和肺毛细血管血容量(VC)]使用Roughton-Forster计算方程。结果年龄、性别和height-standardized转移系数一氧化碳(KCO)和DLCO减少EP-born term-born相比,在青春期和成年早期(假定值为所有时间点和两个组别≤0.04),而肺泡体积是相似的。发展发生在平行于term-born控制,没有发育期赶超增长和下降的迹象在25年(假定值内缺乏并行组0.99,0.65,0.71,0.94,和0.44 z-DLCO, z-VA, z-KCO, DM, VC,分别)。分离膜和血容量组件,发现不太清楚;然而,膜扩散似乎影响最大。Conclusion Pulmonary diffusing capacity was reduced in EP-born compared to term-born, and development from childhood to adulthood tracked in parallel to term-born, with no signs of catch-up growth nor decline at age 25.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Satrell has nothing to disclose.Conflict of interest: Dr. Clemm has nothing to disclose.Conflict of interest: Dr. Røksund has nothing to disclose.Conflict of interest: Dr. Hufthammer has nothing to disclose.Conflict of interest: Dr. Thorsen has nothing to disclose.Conflict of interest: Dr. Halvorsen has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2021/09/24/13993003.04103-2020.full.pdf