TY -的T1 - < em >罗氏菌属mucilaginosa < / em >是一种抗炎细菌慢性肺部疾病患者的呼吸道JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01293 -2021欧元SP - 2101293 AU Rigauts夏洛特盟郎——Aizawa,朱莉安娜AU -泰勒,史蒂文AU -罗杰斯,杰伦特b . AU - Govaerts马提亚AU - Cos,保罗盟——Ostyn丽莎AU -西姆斯,莎拉AU - Vandeplassche,伊娃盟——苏丹尼莫泽什长达盟——Dondelinger Yves盟——Vereecke Lars AU -阿克,本意非盟-辛普森,朱迪·l . AU -毛刺,露西AU -斯,安妮盟,Tunney迈克尔·m . AU - Cigana克里斯蒂娜AU - Bragonzi,亚历山德拉盟——Coenye汤姆AU -克拉布,Aurelie Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/09/16/13993003.01293 - 2021. -抽象N2 -慢性气道炎症在呼吸道疾病发病机制的主要因素,如严重的哮喘,慢性阻塞性肺病(COPD),囊性纤维化(CF)和支气管扩张。当气道炎症的常见病原体的作用被广泛认可,其他微生物群成员的影响还知之甚少。在这里,我们表明,罗氏菌属mucilaginosa,普通居民的口腔也经常检测下呼吸道慢性疾病,对病原菌有抑制作用,LPS-induced促炎症反应,同时体外三维细胞培养模型和体内小鼠模型。此外,在一群成年人与支气管扩张,大量的罗氏菌属种虫害是负相关的炎性标志物(引发IL-1β)和基质金属蛋白酶在痰(金属蛋白酶- 1,MMP-8和MMP-9)。机械的研究表明,r . mucilaginosa抑制NF-κB途径激活的磷酸化通过减少IκB-α因此NF-κB目标基因的表达。这些发现表明,r . mucilaginosa的存在下航空公司可能减轻炎症,这可能反过来影响慢性呼吸系统疾病的严重程度和进展。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。这些生产过程完成后,作者已经批准结果证明,本文将最新一期的ERJ在线。请打开或下载PDF查看这篇文章。利益冲突:夏洛特Rigauts申报相关专利申请这项工作。郎的利益冲突:朱莉安娜Aizawa没有披露。利益冲突:史蒂文泰勒没有披露。Conflict of interest: Geraint B. Rogers has nothing to disclose.Conflict of interest: Matthias Govaerts has nothing to disclose.Conflict of interest: Paul Cos has nothing to disclose.Conflict of interest: Lisa Ostyn has nothing to disclose.Conflict of interest: Sarah Sims has nothing to disclose.Conflict of interest: Eva Vandeplassche has nothing to disclose.Conflict of interest: Mozes Sze has nothing to disclose.Conflict of interest: Yves Dondelinger has nothing to disclose.Conflict of interest: Lars Vereecke has nothing to disclose.Conflict of interest: Heleen Van Acker has nothing to disclose.Conflict of interest: Jodie L. Simpson has nothing to disclose.Conflict of interest: Lucy Burr has nothing to disclose.Conflict of interest: Anne Willems has nothing to disclose.Conflict of interest: Michael M. Tunney has nothing to disclose.Conflict of interest: Cristina Cigana has nothing to disclose.Conflict of interest: Alessandra Bragonzi has nothing to disclose.Conflict of interest: Tom Coenye declare a patent application related to this work.Conflict of interest: Aurélie Crabbé declare a patent application related to this work. ER -