RT期刊文章SR电子T1期望和呼吸困难：呼吸道疾病的神经生物学基础JF欧洲呼吸杂志JO EUR RESSIR J FD欧洲呼不188bet官网地址Büchel，Christian YR 2021 Ul //www.qdcxjkg.com/content/58/3/3/2003008.abstract Abstract Abstract Abs Track Abs，例如不可唤起支气管收缩的气味，可能会变成哮喘患者的触发器。尽管它具有临床意义，但这种呼吸NOCEBO效应的神经基础尚不清楚。我们在涉及36位健康志愿者的功能磁共振成像（fMRI）研究中研究了这种效果。该实验包括一个经验阶段，在该阶段中，志愿者在暴露于有气体的同时经历了呼吸困难（“ Histarinol”）。志愿者被告知，组丁醇通过支气管收缩诱导呼吸困难。将其与另一种没有引起呼吸困难的气体进行了比较。呼吸困难实际上是由插入呼吸系统中隐藏的电阻载荷引起的。在第二个期望阶段，HESTARINOL和对照气体均随后均具有相同的非常轻微的负载。连续记录呼吸参数，并在每次试验后评级呼吸困难的参与者。与对照条件相比，在经验和预期阶段，组心氨酸酚的dyspnoea等级在预期阶段相同。Insula FMRI信号匹配实际载荷，即在体验阶段组性酚和控制之间存在显着差异，但期望阶段没有差异。 The periaqueductal gray showed a significantly higher fMRI signal during the expectation of dyspnoea. Finally, Histarinol-related deactivations during the expectation phase in the rostral anterior cingulate cortex mirrored similar responses for nocebo effects in pain.These findings highlight the neural basis of expectation effects associated with dyspnoea, which has important consequences for our understanding of the perception of respiratory symptoms.A neural dyspnoea nocebo effect was found; expectations of dyspnoea increase the central neural processing of dyspnoea and respiratory effort as seen by activation of the periaqueductal gray and deactivation of the rostral anterior cingulate cortex http://bit.ly/3p2TsA6