TY-JUR T1 - 儿童饮食摄入量，肺功能和哮喘患儿童JF - 欧洲呼吸杂志Jo - EUR RESPIR J DO - 10.1183 / 13993003.04407-2020 SP - 2004407 Au - Talaei，Mohammad Au - Hughes，David A.。Au - Mahmoud，Osama Au - Emmett，Pauline M. Au - Granell，Raquel Au - Guerra，Stefano Au - Shaheen，Seif O. Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/ eAlly/2021/09/119993003.04407-2020.Abstract n2 - 纵向流行病学数据稀缺依据幼儿膳食摄入量和童年呼吸结果的关系。我们调查了中小儿童中预制的维生素A或Provitaminβ-胡萝卜素的更高摄取与肺功能较高，患有青春期的哮喘风险。父母和儿童的纵向研究，预先形成的维生素A和β的膳食摄入量- 在7岁时通过食品频率调查征估计碳焦酮等价物。支气管扩张剂强制呼气量为1 s（FEV1），强制致命能力（FVC）和25-75％的FVC（FEF25-75）的强制呼气流量在15.5岁处测量并转化为Z分数。事件哮喘由新的医生诊断哮喘患者在11或14年龄。多变量调整模型，预先形成的维生素A摄入量较高与肺功量较高，事件哮喘的风险较低：比较顶部与底部四分位数相比摄入量，FEV1和FEF25-75的回归系数（95％置信区间）分别为0.21（0.05-0.38; p趋势0.008）和0.18（0.03-0.32; p趋势0.02）;FEV1 / FVC比率低于正常和入射哮喘下限的差距（95％置信区间）分别为0.49（0.27-0.90，p趋势0.04）和0.68（0.47,0.99; p趋势0.07）。相比之下，没有证据表明与β-胡萝卜素相关。我们还发现了一些证据改变了预先形成的维生素Antake和肺功能之间的关联，NcMO1，Ncor2和CC16基因多态性。在中儿童中，较高的维生素A，但不是β-胡萝卜素的摄入量更高肺功能和较低风险的固定气流限制和事件哮喘。欧洲呼吸杂志最近被接受出版发表的哮喘。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Talaei has nothing to disclose.Conflict of interest: Dr. Hughes has nothing to disclose.Conflict of interest: Dr. Mahmoud has nothing to disclose.Conflict of interest: Dr. Emmett reports grants from Nestle Nutriton, personal fees from European Food Safety Authority, outside the submitted work; .Conflict of interest: Dr. Granell has nothing to disclose.Conflict of interest: Dr. Guerra has nothing to disclose.Conflict of interest: Dr. Shaheen has nothing to disclose. ER -