RT Journal第SR电子T1膳食摄入量的维生素A，肺功能和事件哮喘在儿童时期JF欧洲呼吸杂志Jo EUR Respir J FD欧洲呼吸学会SP 2004407 Do 10.1183 / 13993003.04407-2020 A1 Talaei，Mohammad A1 Hughes，David A.188bet官网地址A1 Mahmoud，Osama A1 Emmett，Pauline M. A1 Granell，Raquel A1 Guerra，Stefano A1 Shaheen，Seif O. YR 2021 UL //www.qdcxjkg.com/content/early/2021 / 09/16/13993003.04407-2020.Abstract AB纵向流行病学数据是稀缺的幼儿膳食摄入与儿童呼吸结果的关系。我们调查了中小儿童中预制的维生素A或Provitaminβ-胡萝卜素的较高摄入是否与肺功能更高的肺功能和青春期的哮喘风险有关。禽流感和儿童的纵向研究，预先形成的维生素A和β的膳食摄入量- 在7岁时通过食品频率问卷估算了喀替烯等价物。支气管扩张剂强制呼气量为1 s（FEV1），强制致命能力（FVC）和25-75％的FVC（FEF25-75）的强制呼气流量在15.5岁处被测量，并转化为Z分数。事件哮喘由新的医生诊断哮喘患者在11或14年龄。多变量调节模型，预先形成的维生素A摄入量较高，与肺功能较高，事件哮喘的风险较低：比较顶部与底部四分位数相比摄入量，FEV1和FEF25-75的回归系数（95％置信区间）分别为0.21（0.05-0.38; p趋势0.008）和0.18（0.03-0.32; p趋势0.02）;FEV1 / FVC比率低于正常和事件哮喘下限的差距（95％置信区间）分别为0.49（0.27-0.90，p趋势0.04）和0.68（0.47,0.99; p趋势0.07）。相比之下，没有证据表明与β-胡萝卜素联系。我们还发现了一些证据通过BCMO1，Ncor2和CC16基因多态性进行了预先形成的维生素A摄入和肺功能之间的关联的证据。在中儿童中摄入更高的预制维生素A，但不是β-胡萝卜素与较高的后期相关联肺功能和较低的固定气流限制和事件哮喘的风险。最近在欧洲呼吸杂志中公布的公布被接受了Footnotesthis稿件。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Talaei has nothing to disclose.Conflict of interest: Dr. Hughes has nothing to disclose.Conflict of interest: Dr. Mahmoud has nothing to disclose.Conflict of interest: Dr. Emmett reports grants from Nestle Nutriton, personal fees from European Food Safety Authority, outside the submitted work; .Conflict of interest: Dr. Granell has nothing to disclose.Conflict of interest: Dr. Guerra has nothing to disclose.Conflict of interest: Dr. Shaheen has nothing to disclose.