TY - T1的膳食摄入的维生素A,肺功能,在儿童时期和事件哮喘JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.04407 -2020欧元SP - 2004407 AU Talaei穆罕默德AU -休斯,David A . AU -马哈茂德,奥萨马AU -艾美特,波林m . AU - Granell拉奎尔盟——Guerra斯特凡诺盟,夏新,Seif O. Y1 - 2011/01/01 UR - //www.qdcxjkg.com/content/early/2021/09/16/13993003.04407-2020.abstract N2 -儿童时期维生素A膳食摄入与呼吸结局之间关系的纵向流行病学数据很少。我们调查了儿童期中期较高的维生素a或维生素原β-胡萝卜素摄入量是否与较高的肺功能和青少年哮喘风险有关。在雅芳父母和儿童的纵向研究中，通过7岁时的食物频率问卷估计了预制维生素A和β-胡萝卜素等量的饮食摄入量。15.5年时测量支气管扩张剂后1秒用力呼气量(FEV1)、用力肺活量(FVC)和用力呼气流量(FVC的25-75%)，并转换为z评分。哮喘发病率的定义是在11或14岁时被医生诊断为哮喘的新病例。在多变量调整模型中，较高的维生素a摄入量与较高的肺功能和较低的哮喘发病风险相关:比较摄入的顶部和下方四分位数，FEV1和FEF25-75的回归系数(95%置信区间)分别为0.21 (0.05-0.38;p -趋势0.008)和0.18 (0.03-0.32;P-trend 0.02);FEV1/FVC比值低于正常和哮喘发病下限的比值比(95%可信区间)分别为0.49 (0.27 ~ 0.90,p趋势0.04)和0.68 (0.47,0.99; P-trend 0.07). In contrast, there was no evidence for association with β-carotene. We also found some evidence for modification of the associations between preformed vitamin A intake and lung function by BCMO1, NCOR2 and CC16 gene polymorphisms.A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Talaei has nothing to disclose.Conflict of interest: Dr. Hughes has nothing to disclose.Conflict of interest: Dr. Mahmoud has nothing to disclose.Conflict of interest: Dr. Emmett reports grants from Nestle Nutriton, personal fees from European Food Safety Authority, outside the submitted work; .Conflict of interest: Dr. Granell has nothing to disclose.Conflict of interest: Dr. Guerra has nothing to disclose.Conflict of interest: Dr. Shaheen has nothing to disclose. ER -