AU - Talaei, Mohammad AU - Hughes, David A. AU - Mahmoud, Osama AU - Emmett, Pauline M. AU - Granell, Raquel AU - Guerra, Stefano AU - Shaheen, Seif O. TI -膳食维生素A摄入量，肺功能，和事件哮喘儿童援助- 10.1183/13993003.04407 -2020 DP - 2021年1月01 TA -欧洲呼吸杂志PG - 2004407 4099 - //www.qdcxjkg.com/content/early/2021/09/16/13993003.04407 - 2020. -短4100 - //www.qdcxjkg.com/content/early/2021/09/16/13993003.04407 - 2020. -完整的AB -纵向流行病学数据稀缺膳食维生素A摄入量与儿童呼吸转归的关系我们调查了儿童中期较高的预合成维生素a或维生素原β-胡萝卜素摄入量是否与更高的肺功能和青少年哮喘风险有关。在雅芳对父母和儿童的纵向研究中，通过食物频率问卷对7岁儿童的预制维生素A和β-胡萝卜素当量的膳食摄入量进行了估计。15.5年测量支气管扩张器后1秒用力呼气量(FEV1)、用力肺活量(FVC)和25-75%用力呼气流量(FEF25-75)，并转化为z评分。发作性哮喘的定义是在11或14岁时医生诊断出的哮喘新病例。在多变量调整模型中，较高的预制成维生素a摄入量与较高的肺功能和较低的哮喘发作风险相关:与最高四分位数摄入量相比，FEV1和ff25 - 75的回归系数(95%置信区间)分别为0.21 (0.05-0.38;p -趋势0.008)和0.18 (0.03-0.32;P-trend 0.02); odds ratios (95% confidence intervals) for FEV1/FVC ratio below the lower limit of normal and incident asthma were, respectively, 0.49 (0.27–0.90, P-trend 0.04) and 0.68 (0.47, 0.99; P-trend 0.07). In contrast, there was no evidence for association with β-carotene. We also found some evidence for modification of the associations between preformed vitamin A intake and lung function by BCMO1, NCOR2 and CC16 gene polymorphisms.A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Talaei has nothing to disclose.Conflict of interest: Dr. Hughes has nothing to disclose.Conflict of interest: Dr. Mahmoud has nothing to disclose.Conflict of interest: Dr. Emmett reports grants from Nestle Nutriton, personal fees from European Food Safety Authority, outside the submitted work; .Conflict of interest: Dr. Granell has nothing to disclose.Conflict of interest: Dr. Guerra has nothing to disclose.Conflict of interest: Dr. Shaheen has nothing to disclose.