TY -的T1 COVID-19气胸在英国:aprospective observational study using the ISARIC WHO clinical characterisation protocol JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00929-2021 VL - 58 IS - 3 SP - 2100929 AU - Marciniak, Stefan J. AU - Farrell, James AU - Rostron, Anthony AU - Smith, Ian AU - Openshaw, Peter J.M. AU - Baillie, J. Kenneth AU - Docherty, Annemarie AU - Semple, Malcolm G. Y1 - 2021/09/01 UR - //www.qdcxjkg.com/content/58/3/2100929.abstract N2 - Pneumothorax is an important complication of coronavirus disease 2019 (COVID-19) [1, 2]. Based on a series of 60 individuals, we previously estimated that 0.91% of people admitted to hospital with COVID-19 develop pneumothorax [1]. Males accounted for three quarters of those affected, and patients requiring noninvasive or invasive ventilatory support appeared at elevated risk. In a separate series of ventilated patients with COVID-19, barotrauma, defined as pneumothorax or pneumomediastinum, was found to be an independent risk for death [2]. During the pandemic, treatment strategies have evolved, influenced by large randomised controlled trials and clinical experience. Following the landmark results from the RECOVERY trial [3], dexamethasone became standard of care for patients requiring supplemental oxygen. Following the first UK wave between March and June 2020, use of noninvasive respiratory support became more common [4, 5]. Such changes could plausibly alter the incidence of pneumothorax caused by COVID-19. Indeed, a recent small study reported an increase in pneumothoraces in the second wave of COVID-19 in Italy, leading to speculation that dexamethasone use might have been causal [6].Population level data from 131 679 patients show that COVID-19 pneumothorax occurs in 0.97% of admitted patients, especially males and smokers, and is associated with increased mortality https://bit.ly/3oB27ezWe are grateful to the 2648 frontline clinical and research staff and medical students who collected these data in the most challenging of times, and to the thousands of NHS staff who cared for these patients. ER -