TY -的T1 -爆发的pre -博士和广泛ug-resistant tuberculosis in northern Italy: urgency of cross-border, multidimensional, surveillance systems JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00839-2021 VL - 58 IS - 3 SP - 2100839 AU - Villa, Simone AU - Tagliani, Elisa AU - Borroni, Emanuele AU - Castellotti, Paola Francesca AU - Ferrarese, Maurizio AU - Ghodousi, Arash AU - Lamberti, Anna AU - Senatore, Sabrina AU - Faccini, Marino AU - Cirillo, Daniela Maria AU - Codecasa, Luigi Ruffo Y1 - 2021/09/01 UR - //www.qdcxjkg.com/content/58/3/2100839.abstract N2 - Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are a major public health threat because of reduced treatment options and poor patient outcomes. New antimicrobials and regimens have been developed in recent years, but their effectiveness has been hampered by the rise and spread of drug-resistant strains. Whole genome sequencing (WGS) has emerged as a tool able to revolutionise TB surveillance and the clinical management of TB. This approach is now widely used by public health agencies in detecting outbreaks and transmission chains, thus supporting the formulation of evidence-based health policies. Moreover, WGS can predict the drug-susceptibility profile of Mycobacterium tuberculosis complex (MTBC) strains, often in combination with phenotypic antimicrobial susceptibility testing (AST) and minimum inhibitory concentration (MIC) determination for the optimal clinical management of drug-resistant TB [1].An outbreak of (pre-)extensively drug-resistant tuberculosis was detected in Northern Italy using whole genome sequencing and epidemiological study. This experience suggests that integrated and cross-border surveillance systems should be urgently employed. https://bit.ly/3wtQkBpWe would like to thank Ester Mazzola and Stefania Torri of the Regional TB Reference Laboratory, ASST Niguarda (Milan, Italy) for their technical contribution in the preliminary molecular assessment of TB samples of the clustered cases hereby described; and Alberto Trovato of the Emerging Bacterial Pathogens Unit of the IRCCS San Raffaele Scientific Institute (Milan, Italy) for technical assistance in WGS analyses of TB samples. ER -