TY - JOUR T1 -炎症与血栓之间:内皮细胞在COVID-19 JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00377 -2021欧元六世- 58 - 3 SP - 2100377 AU Birnhuber安娜AU - Fließ呃,伊丽莎白盟——Gorkiewicz格雷戈尔盟——撒迦利亚,马丁盟——Seeliger本杰明盟——大卫,Sascha盟——Welte Tobias AU -施密特,朱利叶斯盟——Olschewski严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)正在引起当前的冠状病毒病(COVID-19)大流行[1]。近几个月来，发表了大量涉及该疾病多个方面和表现的新颖研究文章。越来越多的证据表明，内皮细胞在SARS-CoV-2感染中发挥着重要作用[2-5]。早期研究表明，COVID-19肺组织[2]中血管和炎症因子(如血管细胞粘附分子(VCAM)-1、白细胞介素(IL)-8或单核细胞趋化蛋白(MCP)-1)表达增加。这些内皮功能障碍和内皮细胞完整性改变的标志物是SARS-CoV-2感染[6]预后不良的重要预测指标，它们与肺水肿、血管内血栓和急性呼吸窘迫综合征(ARDS)有关。肺内皮细胞在调节血管张力、炎症反应、凝血/纤溶和维持血管稳态和通透性方面起着至关重要的作用。对这些受到严格管制的过程的干扰可能直接导致发病率和死亡率。然而，导致COVID-19肺血管病变的确切机制仍不清楚。 Here, we provide an analysis of several important vascular markers implicated in the inflammatory response (E-selectin, intercellular cell adhesion molecule (ICAM)-1, VCAM-1), maintenance of microvascular integrity (CD31, vascular endothelial growth factor receptor (VEGFR)-2), platelet activation and coagulation (P-selectin, von Willebrand factor (vWF)) in lung tissue and plasma samples of COVID-19 patients.Elevated levels of several endothelial markers, including CD31, VEGFR-2, ICAM-1, VCAM-1, E-selectin, P-selectin and vWF, in lung tissue and circulation support an important role of the pulmonary endothelium in local and systemic COVID-19 pathology https://bit.ly/3eQObIRWe would like to thank Simone Tischler and Thomas Fuchs for excellent technical assistance. The authors thank the Institute for Clinical Immunology and Transfusion Medicine, Universities of Giessen and Marburg Lung Center (UGMLC) for the acquisition and provision of control plasma samples. ER -