TY - T1的急性呼吸窘迫综合征与肺泡巨噬细胞受损efferocytosis JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00829 -2021欧元六世- 58 - 3 SP - 2100829 AU Mahida拉胡尔y . AU -斯科特,亚伦AU -帕尔克,Dhruv AU - Lugg,塞巴斯蒂安·t . AU -哈迪,罗文s . AU -拉威利加雷斯·g . AU - Matthay Michael a . AU - Naidu先生AU -帕金斯,加文·d . AU - Thickett David r . Y1 - 2021/09/01 UR - //www.qdcxjkg.com/content/58/3/2100829.abstract N2 -急性呼吸窘迫综合征(ARDS)是一种炎症性疾病的肺部,与脓毒症的主要病因学。尽管通气策略取得了进展，但中度至重度ARDS的死亡率仍保持在40-46%[1]。急性呼吸窘迫综合征伴有中性粒细胞流入肺泡。支气管肺泡灌洗液中持续高的中性粒细胞和低的肺泡巨噬细胞(AM)数量与较高的死亡率[2]相关。虽然早期ARDS的炎症肺泡环境最初延迟了细胞凋亡，但这些中性粒细胞最终在肺泡[3]内发生凋亡。AMs对凋亡的中性粒细胞有效的泡状细胞作用是解决炎症[3]的关键。急性呼吸窘迫综合征(ARDS)中，凋亡的中性粒细胞可能由于AM泡沫化功能缺陷和/或泡沫化功能过度而积聚，然后发生继发性坏死，释放炎症介质到肺泡间隙[4]。这可能与ARDS中观察到的炎症延长有关。此前没有研究评估急性呼吸窘迫综合征(ARDS)中AM的泡沫化; however, monocyte-derived macrophages (MDMs) from ARDS patients do have impaired efferocytosis [5]. We investigated whether ARDS patients have impaired AM efferocytosis and increased alveolar neutrophil apoptosis.ARDS patients have decreased alveolar macrophage efferocytosis, which is associated with increased alveolar inflammation, and may contribute to worse clinical outcomes, including mortality. Upregulation of efferocytosis may offer a therapeutic strategy. https://bit.ly/2Q7REdM ER -