作者@article {Osorio2101649 ={奥索里奥,里卡多S. and Mart{\'\i}nez-Garc{\'\i}a, Miguel {\'A}ngel and Rapoport, David M.}, title = {Sleep apnoea in the elderly: a great challenge for the future}, elocation-id = {2101649}, year = {2021}, doi = {10.1183/13993003.01649-2021}, publisher = {European Respiratory Society}, abstract = {Due in part to overall improvements in health, the population of elderly individuals is increasing rapidly. Similarly, obstructive sleep apnoea (OSA) is both gaining increased recognition and also increasing due to the worldwide obesity epidemic. The overlap of OSA and aging is large, but there is strong plausibility for causation in both directions: OSA is associated with pathological processes that may accelerate aging and aging related processes; aging may cause physical and neurological changes that predispose to obstructive (and central) apnoea. In addition, the common symptoms (e.g. excessive daytime somnolence, defects in memory and cognition), possible physiological consequences of OSA (e.g. accelerated cardiovascular and cerebrovascular atherosclerosis), and changes in metabolic and inflammatory markers overlap with the symptoms and associated conditions seen in aging. There is also the possibility of synergy in the effects of these symptoms and conditions on quality of life, as well as a need to separate treatable consequences of OSA from age-related complaints. Taken together, the above make it essential to review the interaction of OSA and aging, both proven and suspected. The present review examines some aspects of what is known and points to the need for further investigation of the relationships, given the large number of potentially affected subjects.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: For complete conflict of interest, see the ICJME documents}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2021/08/26/13993003.01649-2021}, eprint = {//www.qdcxjkg.com/content/early/2021/08/26/13993003.01649-2021.full.pdf}, journal = {European Respiratory Journal} }