PT -期刊文章盟Rogliani Paola盟——罗切斯特理工学院的航拍ondo, Beatrice Ludovica AU - Calzetta, Luigino TI - Triple therapy in uncontrolled asthma: a network meta-analysis of phase III studies AID - 10.1183/13993003.04233-2020 DP - 2021 Sep 01 TA - European Respiratory Journal PG - 2004233 VI - 58 IP - 3 4099 - //www.qdcxjkg.com/content/58/3/2004233.short 4100 - //www.qdcxjkg.com/content/58/3/2004233.full SO - Eur Respir J2021 Sep 01; 58 AB - Conflicting evidence is currently available concerning the impact on asthma exacerbation of triple inhaled corticosteroid (ICS)/long-acting β2-adrenoceptor agonist (LABA)/long-acting muscarinic receptor antagonist (LAMA) fixed-dose combination (FDC).Since meta-analyses allow settling controversies of apparently inconsistent results, we performed a network meta-analysis of phase III randomised controlled trials including 9535 patients to assess the effect of ICS/LABA/LAMA combinations in uncontrolled asthma.Triple combination therapies with an ICS administered at high dose (HD) were more effective (p<0.05) than medium-dose (MD) ICS/LABA/LAMA FDC and both MD and HD ICS/LABA FDCs against moderate to severe exacerbation (relative risk 0.61–0.80) and increasing trough forced expiratory volume in 1 s (from +33 to +114 mL). Triple combination therapies including HD ICS were superior (p<0.05) to MD ICS/LABA/LAMA FDC in preventing severe exacerbation (relative risk 0.46–0.65), but not with respect to moderate exacerbation (p>0.05). Triple combination therapies were equally effective on asthma control, with no safety concerns.This quantitative synthesis suggests that ICS/LABA/LAMA FDCs are effective and safe in uncontrolled asthma, and that the dose of ICS in the combination represents the discriminating factor to treat patients with a history of moderate or severe exacerbation.Triple combination therapy by adding either a LAMA to ICS/LABA FDC or escalating ICS on a background of ICS/LABA/LAMA FDC may reduce severe exacerbations and improve lung function; adding a LAMA along with escalating ICS provides incremental effects https://bit.ly/39NuNKb