PT -期刊文章AU -穆罕默德Talaei盟Emmanouela Sdona AU -菲利普·c·考尔德盟路易丝·r·琼斯AU -波林·m·艾美特盟拉奎尔Granell AU -安娜Bergstrom AU - Erik Melen AU -赛义夫o . Shaheen TI -摄入量< em > n < / em > 3多不饱和脂肪酸在童年,< em >时尚< / em >基因型和事件哮喘援助- 10.1183/13993003.03633 -2020 DP - 2021年9月01 TA -欧洲呼吸杂志》第六PG - 2003633 - 58 IP - 3 4099 - //www.qdcxjkg.com/content/58/3/2003633.short 4100 - //www.qdcxjkg.com/content/58/3/2003633.full所以欧元和J2021 9月01;58 AB -纵向证据之间的关系饮食摄入量的n - 3(ω-3)very-long-chain多不饱和脂肪酸,即二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),在mid-childhood和哮喘风险是稀缺的。我们旨在调查是否摄入EPA和DHA的鱼在童年与降低事件发生哮喘的风险有关。的“埃文亲子纵向研究和儿童,膳食摄入EPA和DHA的鱼被食物频率问卷估计在7岁。我们使用逻辑回归,控制混杂因素,分析之间的关联摄入EPA和DHA(四分位数)和医生诊断哮喘的发病率在11岁或14年,由脂肪酸和探索潜在影响修改desaturase(时尚)多态性(rs1535)。复制在瑞典寻求BAMSE出生队列。没有证据表明之间的关系从鱼和事件摄入EPA + DHA哮喘整体(n = 4543)。然而,当分层的时尚基因型,比较优势比顶部和底部之间的四分位数2025小G等位基因携带者为0.49 (95% CI 0.31 - -0.79;ptrend = 0.006),但没有观察到负相关在等位基因纯合子的主要组(或1.43,95%可信区间0.83 - -2.46;ptrend = 0.19) (pinteraction = 0.006)。 This gene–nutrient interaction on incident asthma was replicated in BAMSE.In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence.In children with a common fatty acid desaturase (FADS) variant, higher intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish in mid-childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence https://bit.ly/2M4VxO6