% 0期刊文章% Mohammad Talaei % Emmanouela Sdona %一个路易斯·r·琼斯菲利普·c·考尔德% %一个拉奎尔Granell波林·m·艾美特% % %斯通安娜Erik Melen %赛义夫o . Shaheen % T的摄入量n3多不饱和脂肪酸的童年,时尚基因型和事件哮喘% D J 2021% R 10.1183/13993003.03633 -2020%欧洲呼吸杂志% P 2003633 % V 58% N 3% X纵向证据之间的关系饮食摄入量的N - 3(ω-3)very-long-chain多不饱和脂肪酸,即二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),在mid-childhood和哮喘风险是稀缺的。我们旨在调查是否摄入EPA和DHA的鱼在童年与降低事件发生哮喘的风险有关。的“埃文亲子纵向研究和儿童,膳食摄入EPA和DHA的鱼被食物频率问卷估计在7岁。我们使用逻辑回归,控制混杂因素,分析之间的关联摄入EPA和DHA(四分位数)和医生诊断哮喘的发病率在11岁或14年,由脂肪酸和探索潜在影响修改desaturase(时尚)多态性(rs1535)。复制在瑞典寻求BAMSE出生队列。没有证据表明之间的关系从鱼和事件摄入EPA + DHA哮喘整体(n = 4543)。然而,当分层的时尚基因型,比较优势比顶部和底部之间的四分位数2025小G等位基因携带者为0.49 (95% CI 0.31 - -0.79;ptrend = 0.006),但没有观察到负相关在等位基因纯合子的主要组(或1.43,95%可信区间0.83 - -2.46;ptrend = 0.19) (pinteraction = 0.006)。这gene-nutrient交互事件哮喘BAMSE中复制过来。In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence.In children with a common fatty acid desaturase (FADS) variant, higher intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish in mid-childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence https://bit.ly/2M4VxO6 %U //www.qdcxjkg.com/content/erj/58/3/2003633.full.pdf