RT Journal Article SR Electronic T1 Prediction of ventilator-associated pneumonia outcomes according to the early microbiological response: a retrospective observational study JF European Respiratory Journal JO Eur Respir J FD 188bet官网地址European Respiratory Society SP 2100620 DO 10.1183/13993003.00620-2021 A1 Ceccato, Adrian A1 Dominedò, Cristina A1 Ferrer, Miquel A1 Martin-Loeches, Ignacio A1 Barbeta, Enric A1 Gabarrús, Albert A1 Cillóniz, Catia A1 Ranzani, Otavio T. A1 De Pascale, Gennaro A1 Nogas, Stefano A1 Di Giannatale, Pierluigi A1 Antonelli, Massimo A1 Torres，Antoni YR 2021 UL //www.qdcxjkg.com/content/early/2021/08/19/13993003.003003.00620-2021.Abstract ab Abstract ab ab ventilator-相关肺炎是导致严重病人患者疾病的领先感染性原因；然而，当前的指南没有提供随访培养的迹象。我们旨在评估随访培养物和微生物学反应的作用3天后，诊断出呼吸机相关的肺炎作为短期和长期结果的预测指标。我们进行了回顾性分析从2004年到2017年的前瞻性收集的队列中。根据临床，放射学和微生物学标准诊断出呼吸机相关的肺炎。为了进行微生物学鉴定，在诊断时进行了气管机管运动液，并在​​72小时后重复。我们在比较了两组气管机管运动结果时定义了三组：持久性，超级感染和消除病原体。一百五十七名患者参与了研究，其中有微生物学的持久性，超级感染和消除在67（67（67）（72hs之后，分别为48％），25（16％）和65（41％）。超级感染的人在重症监护室中的死亡率最高（p = 0.015），在90天（p = 0.036），同时也没有最少的无通风天（p = 0.024）。多变量分析显示在VAP诊断时发生了冲击（优势比[OR] 3.43; 95％置信区间[CI] 1.25至9.40），金黄色葡萄球菌在VAP诊断时隔离（OR 2.87; 95％CI 1.06至7.75），以及VAP诊断时的低温下降症状。（OR 0.67; 95％CI 0.48至0.95，每 +1°C）与超级感染相关。您的回顾性分析表明，在随访培养物中，短期和长期结局与呼吸机相关的短期和长期结局可能与超级感染有关。后续培养物可能有助于指导抗生素疗法及其持续时间。需要进一步的前瞻性研究来验证我们的发现。最近在《欧洲呼吸道》杂志上被接受了手稿。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Ceccato has nothing to disclose.Conflict of interest: Dr. Dominedo has nothing to disclose.Conflict of interest: Dr. Ferrer has nothing to disclose.Conflict of interest: Dr. Martin-Loeches has nothing to disclose.Conflict of interest: Dr. Barbeta has nothing to disclose.Conflict of interest: Mr. Gabarrús has nothing to disclose.Conflict of interest: Dr. Cilloniz has nothing to disclose.Conflict of interest: Dr. Ranzani has nothing to disclose.Conflict of interest: Dr. De Pascale has nothing to disclose.Conflict of interest: Dr. Nogas has nothing to disclose.Conflict of interest: Dr. Di Giannatale has nothing to disclose.Conflict of interest: Dr. Antonelli has nothing to disclose.Conflict of interest: Dr. Torres has nothing to disclose.