TY - T1的哮喘,慢性阻塞性肺病和SARS-CoV-2 infection (COVID-19): potential mechanistic insights JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00920-2021 VL - 58 IS - 2 SP - 2100920 AU - Wark, Peter A.B. AU - Pathinayake, Prabuddha S. AU - Eapen, Mathew Suji AU - Sohal, Sukhwinder Singh Y1 - 2021/08/01 UR - //www.qdcxjkg.com/content/58/2/2100920.abstract N2 - We read with interest the manuscripts [1, 2] and the accompanying editorial [3] describing the risk of severe disease and infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and asthma, but are struck by the difference seen with risk of complications from asthma and coronavirus disease 2019 (COVID-19) compared to the experience during the 2009 influenza pandemic, where people with asthma were clearly at heightened risk, at least of hospitalisation [4]. In contrast, those who smoke or have COPD, appear at greater risk. Observational studies will never be able to provide evidence of cause and effect and a greater understanding of the mechanisms of susceptibility to infection with SARS-CoV-2 is also required. Hence, we would like to take this further and enhance discussion on potential mechanisms (figure 1).Patients with asthma are somewhat protected from COVID-19 complications compared to COPD. This may be due to variability in viral attachment protein, ICS use, smoking/vaping status, a skewed inflammatory pattern, and dysregulated endocytic machinery. https://bit.ly/3qOcyNb ER -