ty -jour t1-德国晚期疾病患者的专业呼吸困难服务的有效性：务实的快速轨道随机对照试验（呼吸）JF-欧洲呼吸杂志JO -EUR RESSIR J DO -10.1183/13993003.02139-2020-2020-2020 vl -58-58IS - 2 SP - 2002139 AU - Schunk, Michaela AU - Le, Lien AU - Syunyaeva, Zulfiya AU - Haberland, Birgit AU - Tänzler, Susanne AU - Mansmann, Ulrich AU - Schwarzkopf, Larissa AU - Seidl, Hildegard AU - Streitwieser,Sabine au -Hofmann，Miriam au -Müller，Thomas au -Weiß，Tobias au -Morawietz，Philipp au -Rehfuess，Eva Annette Au- Huber- Huber- Huber，Rudolf Maria au- Berger-伯格 -ur -http：//www.qdcxjkg.com/content/58/2/2/2002139.Abstract N2-背景慕尼黑呼吸困难（MBS），整合姑息治疗，呼吸医学和物理疗法，在呼气试验中测试在晚期疾病和慢性呼吸困难的患者中IR Carers.Methods呼吸症是一项单盲随机对照快速试验。MBS参加了5-6周；对照组经过8周的标准护理，开始了MBS。通过癌症和护理人的存在对随机分层进行分层。Primary outcomes were patients’ mastery of breathlessness (Chronic Respiratory Disease Questionnaire (CRQ) Mastery), quality of life (CRQ QoL), symptom burden (Integrated Palliative care Outcome Scale (IPOS)) and carer burden (Zarit Burden Interview (ZBI)). Intention-to-treat (ITT) analyses were conducted with hierarchical testing. Effectiveness was investigated by linear regression on change scores, adjusting for baseline scores and stratification variables. Missing values were handled with multiple imputation.Results 92 patients were randomised to the intervention group and 91 patients were randomised to the control group. Before the follow-up assessment after 8 weeks (T1), 17 and five patients dropped out from the intervention and control groups, respectively. Significant improvements in CRQ Mastery of 0.367 (95% CI 0.065–0.669) and CRQ QoL of 0.226 (95% CI 0.012–0.440) score units at T1 in favour of the intervention group were seen in the ITT analyses (n=183), but not in IPOS. Exploratory testing showed nonsignificant improvements in ZBI.Conclusions These findings demonstrate positive effects of the MBS in reducing burden caused by chronic breathlessness in advanced illness across a wide range of patients. Further evaluation in subgroups of patients and with a longitudinal perspective is needed.The effectiveness of the Munich Breathlessness Service (MBS) was tested in a single-blinded randomised controlled fast-track trial. Significant improvements were shown in mastery of breathlessness and quality of life in patients with advanced illness. https://bit.ly/3nT8jfT ER -