TY - T1的肺血管resista升高nce predicts mortality in COPD patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00944-2021 VL - 58 IS - 2 SP - 2100944 AU - Zeder, Katarina AU - Avian, Alexander AU - Bachmaier, Gerhard AU - Douschan, Philipp AU - Foris, Vasile AU - Sassmann, Teresa AU - Troester, Natascha AU - Brcic, Luka AU - Fuchsjaeger, Michael AU - Marsh, Leigh Matthew AU - Maron, Bradley A. AU - Olschewski, Horst AU - Kovacs, Gabor Y1 - 2021/08/01 UR - //www.qdcxjkg.com/content/58/2/2100944.abstract N2 - COPD is frequently associated with mild to moderate pulmonary hypertension (PH). However, a small subset of patients develops severe PH, which is currently haemodynamically defined as mean pulmonary arterial pressure (mPAP) ≥35 mmHg, or mPAP ≥25 mmHg in combination with cardiac index <2.0 L·min−1·m−2 [1, 2]. These cut-offs are, however, arbitrary and mainly based on expert opinion. In this study we aimed to determine prognostically relevant haemodynamic thresholds for severe PH in COPD by using an unbiased approach.PVR >5 WU proved to be the strongest independent haemodynamic predictor of mortality in COPD patients. This threshold may best identify COPD patients with severe pulmonary vascular disease. https://bit.ly/3v4QE96We thank Daniela Kleinschek for excellent assistance. We thank PH Austria Research Association and Self-Help Organization for their support. ER -