TY - JOUR T1 - 2019年哮喘和冠状病毒病a systematic review and meta-analysis JF - European Respiratory Journal JO - Eur Respiratory J DO - 10.1183/13993003.01209-2021 SP - 2101209 AU - Sunjaya, Anthony P. AU - Allida, Sabine M. AU - Di Tanna, Gian Luca AU - Jenkins关于COVID-19导致的哮喘患者的易损性和死亡风险，个体病例系列和队列研究报告了相互矛盾的结果。研究问题哮喘患者感染、住院或COVID-19临床结果较差的风险更高吗?方法基于2019年12月1日至2021年7月11日世界卫生组织COVID-19数据库等5个主要数据库，对对照组(非哮喘组)的研究进行系统回顾和meta分析。使用Sidik-Jonkman随机效应荟萃分析汇总患病率和风险比。结果51项研究汇集了COVID-19阳性病例中哮喘患者的流行率为8.08% (95% CI 6.87-9.30)。感染COVID-19的风险比为0.83 (95% CI 0.73-0.95, p=0.01);住院率为1.18 (95% CI 0.98-1.42, p=0.08);1.21 (95% CI 0.97-1.51, p=0.09) ICU入院;使用呼吸机的患者为1.06 (95% CI 0.82-1.36, p=0.65)和0.94 (95% CI 0.76-1.17; p=0.58) for mortality for people with asthma. Subgroup analyses by continent revealed a significant difference in risk of acquiring COVID-19, ICU admission, ventilator use and death between the continents.Interpretation The risk of being infected with SARS-CoV-2 was reduced compared to the non-asthma group. No statistically significant differences in hospitalisation, ICU admission and ventilator use were found between groups. Subgroup analyses showed significant differences in outcomes from COVID-19 between America, Europe and Asia. Additional studies are required to confirm this risk profile, particularly in Africa and South America where few studies originate.The risk of being infected with SARS-CoV-2 was reduced compared to the non-asthma group. No significant differences in hospitalisation, ICU admission, ventilator use and mortali were found between groups. ER -