% 0期刊文章%一个以斯帖Wittermans % Stefan M.T. Vestjens %西蒙尼威廉·l·勃洛克m.c Spoorenberg % % 1 c·格拉特案的裁决%罗布·詹森%一个蒙古包T . Rijkers %弗兰克W.J.M. Smeenk % g .保罗Voorn % Ewoudt M.W. van de加尔达%威廉简·w·Bos % Santeon-CAP研究小组% T辅助治疗口服地塞米松non-ICU:社区获得性肺炎患者住院:一个随机临床试验% D J 2021% R 10.1183/13993003.02535 -2020%欧洲呼吸杂志% P 2002535 % V 58% N 2% X背景辅助静脉注射皮质类固醇治疗被证明能减少的长度(LOS)呆在医院治疗社区获得性肺炎(CAP)的成年人。我们旨在评估口服地塞米松在洛杉矶的影响,这种影响是否疾病严重程度相关的。方法在这个多中心、分层随机、双盲、安慰剂对照试验,免疫活性的成人帽被随机分配比例(1:1)接受口服地塞米松(6毫克每日一次)或安慰剂4天在四个教学医院在荷兰。随机(4块)被帽严重程度分层(肺炎严重程度指数类》和IV-V)。主要结果是洛杉矶。结果2012年12月至2018年11月,401名患者随机接受地塞米松(n = 203)或安慰剂(n = 198)。洛杉矶的中位数为短地塞米松组(4.5天,95%置信区间4.0 - -5.0天)比安慰剂组(5.0天,95%可信区间4.6 - -5.4天;p = 0.033)。内帽严重性子组,洛治疗组之间的差异没有统计学意义。二级ICU入学率低地塞米松臂(5(3%)和14 (7%); p=0.030); 30-day mortality did not differ between groups. In the dexamethasone group the rate of hospital readmission tended to be higher (20 (10%) versus 9 (5%); p=0.051) and hyperglycaemia (14 (7%) versus 1 (1%); p=0.001) was more prevalent.Conclusion Oral dexamethasone reduced LOS and ICU admission rate in adults hospitalised with CAP. It remains unclear for which patients the risk–benefit ratio is optimal.Adjunctive treatment with oral dexamethasone in adults hospitalised with community-acquired pneumonia (CAP) reduced length of stay and ICU admission rate. However, it remains unclear for which CAP subgroup the risk–benefit ratio is optimal. https://bit.ly/35tXfPX %U //www.qdcxjkg.com/content/erj/58/2/2002535.full.pdf