TY - T1的无创通气的结果(NIVO)得分:在慢性阻塞性肺病加重病人的住院死亡率的预测需要辅助通风JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.04042 -2020欧元六世- 58 - 2 SP - 2004042 AU -哈特利,汤姆AU -莱恩,尼古拉斯·d . AU -引导约翰盟——艾略特、马克·w . AU - Sovani Milind p . AU -柯蒂斯,海伦简非盟-富勒,伊丽莎白·r . AU -墨菲,帕特里克•b . AU - Shrikrishna迪盟-刘易斯,Keir e . AU -沃德,尼尔·r . AU -特恩布尔,克里斯·d . AU -哈特,尼古拉斯AU -伯克,斯蒂芬·c·Y1 - 2021/08/01 UR - //www.qdcxjkg.com/content/58/2/2004042.abstract N2 -介绍慢性阻塞性肺病急性加重(AECOPD)并发急性(acidaemic) hypercapnic呼吸衰竭(AHRF)要求通风是常见的。当应用适当的通风大大降低了死亡率。尽管如此,有证据表明糟糕的实践和预后的悲观情绪。临床预测工具可以改善决策关于通风,但没有一个是经常使用的。方法连续与AECOPD患者承认和AHRF辅助通风处理(主要是无创性通气)被确定在两家医院不同的人群。确定先验已知和潜在的预后指数。住院死亡的预测工具使用多变量回归分析推导。未来,进行外部验证暂时分开,地理多样化10-centre研究。试验方法坚持三脚架(透明报告个人的多变量预测模型预测或诊断)的建议。结果推导队列:n = 489,住院死亡率25.4%;验证人:n = 733,住院死亡率20.1%。 Using six simple categorised variables (extended Medical Research Council Dyspnoea score 1–4/5a/5b, time from admission to acidaemia >12 h, pH <7.25, presence of atrial fibrillation, Glasgow coma scale ≤14 and chest radiograph consolidation), a simple scoring system with strong prediction of in-hospital mortality is achieved. The resultant Noninvasive Ventilation Outcomes (NIVO) score had area under the receiver operating curve of 0.79 and offers good calibration and discrimination across stratified risk groups in its validation cohort.Discussion The NIVO score outperformed pre-specified comparator scores. It is validated in a generalisable cohort and works despite the heterogeneity inherent to both this patient group and this intervention. Potential applications include informing discussions with patients and their families, aiding treatment escalation decisions, challenging pessimism and comparing risk-adjusted outcomes across centres.The NIVO score was created to predict in-hospital mortality in exacerbations of COPD requiring assisted ventilation. Prospective validation under real-world conditions in 10 UK hospitals shows it easily outperforms existing alternative scores. https://bit.ly/3oKMZdI ER -