RT期刊文章SR电子T1风险因素与发展相关的肺间质异常摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2003005 10.1183/13993003.03005 -2020签证官58 2 A1 Buendia-Roldan, Ivette A1费尔南德斯,罗萨里奥A1 Mejia, Mayra A1华雷斯,188bet官网地址Fortunato A1 Ramirez-Martinez Gustavo A1 Montes Eduardo A1 Pruneda Ana Karem S. A1 Martinez-Espinosa Karen A1 alarcondionet Aime A1 Herrera Iliana A1 Becerril Carina A1 Chavez-Galan Leslie A1 Preciado Mario A1 Pardo Annie A1 Selman约8-10%的50岁以上人群存在间质性肺异常(ILAs)，但其危险因素尚不确定。方法从墨西哥国家呼吸疾病研究所(Mexican National Institute of Respiratory Diseases)招募的817名肺衰老患者中，有80人(9.7%)表现出ILAs，并与同一队列的564名正常高分辨率计算机断层扫描患者进行比较，以评估人口统计学和功能差异。并从同一个队列中随机选择80个个体作为生物标志物。我们评估了MUC5B变异rs35705950、端粒长度、血清基质金属蛋白酶(MMP)-1、MMP-2、MMP-3、MMP-7、MMP-8、MMP-9、MMP-12、MMP-13、白细胞介素(IL)-6、表面活性剂蛋白(SP)-D、α-Klotho和抵抗素水平。结果ILAs患者多为男性(p<0.005)、年龄大于对照组(p<0.0001)、吸烟者(p=0.01)， MUC5B rs35705950频率较高(OR 3.5, 95% CI 1.3-9.4;P =0.01)，降低了肺对一氧化碳和氧饱和度的扩散能力。抵抗素、IL-6、SP-D、MMP-1、MMP-7和MMP-13在ILAs患者中均显著升高。抵抗素(12±5 vs 9±4 ng·mL−1;p=0.0005)和MMP-13(357±143 vs 298±116 pg·mL−1; p=0.004) were the most increased biomarkers. On follow-up (24±18 months), 18 individuals showed progression which was associated with gastro-oesophageal reflux disease (OR 4.1, 95% CI 1.2–12.9; p=0.02) and in females with diabetes mellitus (OR 5.3, 95% CI 1.0–27.4; p=0.01).Conclusions Around 10% of respiratory asymptomatic individuals enrolled in our lung ageing programme show ILAs. Increased serum concentrations of pro-inflammatory molecules and MMPs are associated with ILAs.Some individuals older than 50 years may present interstitial lung abnormalities which are associated with a greater risk of all-cause mortality. This study provides demographic and molecular factors which may help to identify individuals at higher risk. https://bit.ly/2Lc4y88