% 0期刊文章% Savale, Laurent %一个船长,Satoshi %你,Ly %值得,天使爱美丽% Thuillet,拉斐尔%表象,卡罗尔%勒比较,本杰明% Berrebeh, Nihel %韦尔塔,爱丽丝%洁,泽维尔% Cottin,文森特% Chaouat, Ari % Tromeur,塞西尔%仿羔皮呢,Athenais % Jutant,艾蒂安玛丽% Mercier,奥拉夫% Fadel,埃利Montani %,David A Sitbon, Olivier A Humbert, Marc A Tamura, Yuichi A Guignabert，在肺动脉高压(PAH)的严重程度中，尿酸(UA)与肺动脉高压(PAH)之间存在相关性。但UA是否与发病机制有关尚不清楚。本研究的目的是确定循环尿酸在当前肺动脉高压治疗时代的预后价值，并研究尿酸在肺血管重构中的作用。在基线时测定特发性、遗传性或厌食性PAH的血清尿酸水平，并在法国肺动脉高压网络中首次重新评估。我们研究了对照组和PAH患者肺中的黄嘌呤氧化酶(XO)和电压驱动的尿酸转运体1 (URATv1)的蛋白水平，以及野百合碱(MCT)和Sugen/hypoxia (SuHx)大鼠肺中的野百合碱(MCT)和SuHx的蛋白水平。使用人肺动脉平滑肌细胞(PA-SMCs)和两种肺动脉高压(PH)动物模型进行功能研究。第一次随访时血清尿酸水平高，但基线时不高，与预后不良相关。特发性肺动脉高压患者、MCT和SuHx大鼠重塑肺动脉壁的生成酶XO和URATv1均上调。高UA浓度可促进特发性PAH PA-SMCs的细胞生长，但对对照组PA-SMCs没有促进作用。与这些观察结果一致，恶氧酸诱导的高尿酸血症没有加重mct诱导的大鼠的PH。 Finally, chronic treatment of MCT and SuHx rats with benzbromarone mildly attenuated pulmonary vascular remodelling.UA levels in idiopathic PAH patients were associated with an impaired clinical and haemodynamic profile and might be used as a non-invasive indicator of clinical prognosis during follow-up. Our findings also indicate that UA metabolism is disturbed in remodelled pulmonary vascular walls in both experimental and human PAH.Uric acid (UA) level is associated with poor prognosis in PAH. Local UA production is increased in the remodelled pulmonary vasculature, and inhibition of UA incorporation in PA-SMCs reduces their proliferation and mildly reduces experimental PH. https://bit.ly/2Ll5qXM %U //www.qdcxjkg.com/content/erj/58/2/2000332.full.pdf