%0杂志文章%A Le Pavec, Jérôme %A Valeyre, Dominique %A Gazengel, Pierre %A Holm, Are M. %A Schultz, Hans Henrik %A珀奇，Michael %A Le Borgne, Aurélie %A Reynaud-Gaubert, Martine %A Knoop, Christiane %A Godinas, Laurent %A Hirschi, Sandrine %A Bunel, Vincent %A Laporta, Rosalia %A Harari, Sergio %A Blanchard, Elodie %A Magnusson, Jesper M. %A tisot, Adrien %A Mornex, Jean-François %A Picard, Clément %A Savale, Laurent %A Bernaudin, Jean-François %A Brillet, Pierre- yves %A Nunes，希拉里奥%亨伯特,Marc % Fadel,埃利% Gottlieb, Jens % T为结节病肺移植:结果和预后因素2021% % D J R 10.1183/13993003.03358 -2020%欧洲呼吸杂志% P 2003358 % V 58% N 2% X在结节病研究问题,过去的和正在进行的免疫抑制方案,复发性疾病在移植和肺外肺移植的参与可能会影响结果。我们询问是否可以区分肺结节病的表型，如果可以，它们与肺移植治疗的肺结节病患者的预后有什么关系。我们回顾性分析了112名符合结节病国际诊断标准并于2006年至2019年在16个欧洲中心接受肺或心肺移植的患者的数据。结果患者生存期是主要观察指标。移植时，中位年龄(水区间距(IQR))为52岁(46-59岁);71例(64%)为男性。肺表型个体化如下:1)仅为扩张性纤维化;2)气流阻塞;3)严重肺动脉高压(sPH)和气流阻塞;4) sPH、气流阻塞、纤维化; 5) sPH and fibrosis; 6) airflow obstruction and fibrosis; 7) sPH; and 8) none of these criteria, in 17%, 16%, 17%, 14%, 11%, 9%, 5% and 11% of patients, respectively. Post-transplant survival rates after 1, 3, and 5 years were 86%, 76% and 69%, respectively. During follow-up (median (IQR) 46 (16–89) months), 31% of patients developed chronic lung allograft dysfunction. Age and extended lung fibrosis were associated with increased mortality. Pulmonary fibrosis predominating peripherally was associated with short-term complications.Answer to the study question Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis.Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis. https://bit.ly/2XBfJd6 %U //www.qdcxjkg.com/content/erj/58/2/2003358.full.pdf