TY - JOUR T1 -肺移植治疗结节病:结果和预后因素JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.03358 -2020欧元六世- 58 - 2 SP - 2003358 AU - Le Pavec杰罗姆AU - Valeyre,多米尼克•AU - Gazengel皮埃尔盟——河中沙洲,非盟是m -舒尔茨,汉斯Henrik盟,鲈鱼,迈克尔•AU - Le Borgne Aurelie AU - Reynaud-Gaubert马蒂娜AU -努,克丽丝汀盟——Godinas Laurent盟——Hirschi Sandrine盟——Bunel文森特盟,拉波尔塔猩红热AU -哈拉尔族人,塞吉奥AU -布兰查德,Elodie盟——所以马格努松,Jesper M. AU - Tissot, Adrien AU - Mornex, Jean-François AU - Picard, Clément AU - Savale, Laurent AU - Bernaudin, Jean-François AU - Brillet, Pierre-Yves AU - Nunes, Hilario AU - Humbert, Marc AU - Fadel, Elie AU - Gottlieb, Jens Y1 - 201/08/01 UR - //www.qdcxjkg.com/content/58/2/2003358.abstract N2 -研究问题对于结节病患者，过去和正在进行免疫抑制方案，移植过程中的复发性疾病和肺外受累可能会影响肺移植的结果。我们询问了肺结节病的表型是否可以区分，如果可以，它们与肺移植治疗的肺结节病患者的预后有何关系。我们回顾性分析了2006年至2019年期间在16个欧洲中心接受肺或心肺移植的112例符合结节病国际诊断标准的患者的数据。结果患者生存期为主要预后指标。移植时，中位年龄(四分位差(IQR))为52(46-59)岁;71例(64%)为男性。肺表型个体化如下:1)仅扩展性纤维化;2)气流阻塞; 3) severe pulmonary hypertension (sPH) and airflow obstruction; 4) sPH, airflow obstruction and fibrosis; 5) sPH and fibrosis; 6) airflow obstruction and fibrosis; 7) sPH; and 8) none of these criteria, in 17%, 16%, 17%, 14%, 11%, 9%, 5% and 11% of patients, respectively. Post-transplant survival rates after 1, 3, and 5 years were 86%, 76% and 69%, respectively. During follow-up (median (IQR) 46 (16–89) months), 31% of patients developed chronic lung allograft dysfunction. Age and extended lung fibrosis were associated with increased mortality. Pulmonary fibrosis predominating peripherally was associated with short-term complications.Answer to the study question Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis.Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis. https://bit.ly/2XBfJd6 ER -