% 0期刊文章%一个丽莎Pereverzeva % Fabrice Uhel %埃塞尔彼得斯Sengers %乔管家% Lonneke A van Vught %一个艾玛·e·达文波特凯蒂·l·伯纳姆% %朱利安·c·骑士%奥拉夫·l·克莱莫%一个马克·m·J·马库斯·J·舒尔茨%粗毛格子围巾%布兰登P . Scicluna %一个汤姆·范德调查% % T血白细胞在革兰氏阳性和革兰氏阴性肺炎转录组2021% % D J R 10.1183/13993003.01856 -2021%欧洲呼吸杂志% P 2101856 % X背景革兰氏阳性和革兰氏阴性菌是最常见的病原体在社区获得性肺炎(CAP)在重症监护室(ICU)。本研究的目的是确定主机是否免疫反应不同革兰氏阳性和革兰氏阴性帽入住ICU。方法16主机响应生物标志物提供洞察力在病理生理机制与脓毒症和血白细胞转录组分析限制在ICU住院患者在荷兰两家三级医院。结果309例帽与一个明确的或可能的可能性(由预定义的标准)。病原是74.4%的录取决定。患者承认革兰氏阳性帽(n = 90)和革兰氏阴性帽没有不同于承认关于人口(n = 75),慢性并发症、疾病严重程度和死亡率。宿主生物标志物反映系统性炎症反应,凝血激活和内皮细胞功能,以及血液白细胞转录组,在很大程度上类似的革兰氏阳性和革兰氏阴性帽。血液白细胞转录组之间也是相似的革兰氏阳性和革兰氏阴性帽军团在两个独立的验证。在pathogen-specific层面,肺炎链球菌和大肠杆菌诱导最明显的宿主免疫反应。结论结果和主机响应类似帽危重患者由于革兰氏阳性细菌相比,革兰氏阴性细菌。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。这些生产过程完成后,作者已经批准结果证明,本文将最新一期的ERJ在线。 Please open or download the PDF to view this article.Conflict of interest: Dr. Pereverzeva has nothing to disclose.Conflict of interest: Dr. Uhel has nothing to disclose.Conflict of interest: Dr. Peters Sengers reports grants from Dutch Kidney Foundation (Nierstichting), outside the submitted work.Conflict of interest: Dr. Butler has nothing to disclose.Conflict of interest: Dr. van Vught has nothing to disclose.Conflict of interest: Dr. Burnham has nothing to disclose.Conflict of interest: Dr. Davenport has nothing to disclose.Conflict of interest: Dr. Knight has nothing to disclose.Conflict of interest: Dr. Cremer has nothing to disclose.Conflict of interest: Dr. Schultz has nothing to disclose.Conflict of interest: Dr. Bonten has nothing to disclose.Conflict of interest: Dr. Scicluna has nothing to disclose.Conflict of interest: Dr. van der Poll has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2021/07/29/13993003.01856-2021.full.pdf