% 0期刊文章% Olfa Harki %一个jean - louis Pepin昆汀Boete % %一个爱丽丝Belaidi克莱尔Arnaud % %一个查尔斯艺Gilles Faury % %安妮Briancon-Marjollet % T间歇hypoxia-related血管结构和功能的改变:系统回顾和荟萃分析的啮齿动物数据% D 2021% R 10.1183/13993003.00866 -2021% J欧洲呼吸杂志% P 2100866 % X阻塞性睡眠呼吸暂停和相关间歇性缺氧(IH)被广泛认为是发生心血管疾病的危险因素。许多研究支持IH的有害影响血管的啮齿动物,而是一个整体的解释是挑战由于异质性在啮齿动物物种调查和IH曝光的严重程度和持续时间。澄清这个主要问题,我们进行了系统回顾和荟萃分析量化IH系统性动脉结构和功能的影响取决于不同的IH暴露设计。我们搜索PubMed、Embase和网络科学和荟萃分析包括125篇文章,其中112年利用野生啮齿动物和13载脂蛋白E淘汰赛老鼠。我们使用了标准化平均差(SMD)研究之间的比较结果。IH显著增加平均动脉压(+ 13.90毫米汞柱(95%可信区间(11.88;15.92]),收缩压和舒张压。多元回归结果显示,平均动脉压的变化与应变和出版年份。在男性而不是女性IH改变血管舒张,endothelin-1-induced增加,但不是phenylephrine-induced,血管收缩。显著增加在IH暴露内膜-中膜厚度(SMD 1.10 (0.58;1.62),绝对的值:+ 5.23 (2.81 - -7.84))。增加小鼠观察而不是老鼠,随着年龄的增长,负相关。最后IH增加动脉粥样硬化斑块大小在ApoE−−老鼠(SMD 1.08 (0.80; 1.37]).To conclude, our meta-analysis established that IH, independently of other confounders, has a strong effect on vascular structure and physiology. Our findings support the interest of identifying and treating sleep apnea in routine cardiology practice.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Harki has nothing to disclose.Conflict of interest: Dr. Boete has nothing to disclose.Conflict of interest: Dr. Pépin has nothing to disclose.Conflict of interest: Dr. Arnaud has nothing to disclose.Conflict of interest: Dr. Belaidi has nothing to disclose.Conflict of interest: Dr. Faury has nothing to disclose.Conflict of interest: Dr. Khouri has nothing to disclose.Conflict of interest: Dr. Briançon-Marjollet has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2021/07/29/13993003.00866-2021.full.pdf