TY - JOUR T1 - 单核细胞在结节病是有效的肿瘤坏死因子生产商和预测疾病结果JF - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.03468-2020 VL - 58 - 1个SP - 2003468 AU - Lepzien，波多黎各AU- 柳，桑AU - Czarnewski，圣保罗AU - 聂，沐非盟 - 拥有Österberg，比约恩AU - Baharom，Faezzah AU - Pourazar，Jamshid AU - 兰，格雷戈里AU - Eklund的，安德斯AU - 博塔伊，利玛窦AU - Kullberg，苏珊娜AU- 布隆贝格，安德斯AU - 格鲁内瓦尔德，约翰AU - SMED - 索伦森，安娜Y1 - 2021年7月1日UR - //www.qdcxjkg.com/content/58/1/2003468.abstract N2 - 背景肺结节病是炎性疾病的特征在于肉芽形成和异构的临床结果。肿瘤坏死因子（TNF）是促炎性细胞因子促进肉芽形成和高水平的肿瘤坏死因子已显示出与疾病进展相关联。单核吞噬细胞（的MNP）是肿瘤坏死因子的强效生产者和高度敏感的炎症。在结节病，肺泡巨噬细胞已经得到很好的研究。然而，也的MNP包括单核/单核细胞衍生的细胞和树突状细胞，这是欠缺研究的结节病，尽管他们在inflammation.Objective核心作用，要确定肺单核细胞衍生的细胞和树突状细胞的作用sarcoidosis.Methods我们在执行过程中-depth表型，从血液和支气管肺泡灌洗（BAL）从108名结节病病人和30个健康对照流体MNP子集的功能和转录分析。我们遵循患者的临床开发和评估MNP子集中的诊断剧目和功能如何与2年无病outcome.Results相关单核/单核细胞源性细胞结节病患者血液和BAL分别提高健康对照组相比。有趣的是，在患有慢性疾病发展相关诊断时血单核细胞的中间的高频率。 RNA sequencing analysis showed highly inflammatory MNPs in BAL of sarcoidosis patients. Furthermore, frequencies of BAL monocytes/monocyte-derived cells producing TNF without exogenous stimulation at time of diagnosis increased in patients that were followed longitudinally. In contrast to alveolar macrophages, the frequency of TNF-producing BAL monocytes/monocyte-derived cells at time of diagnosis was highest in sarcoidosis patients that developed progressive disease.Conclusion Our data show that pulmonary monocytes/monocyte-derived cells are highly inflammatory and can be used as a predictor of disease outcome in sarcoidosis patients.Phenotypic, transcriptomic and functional mapping of blood and pulmonary mononuclear phagocytes in sarcoidosis patients found that frequency and function of pulmonary monocytes at time of diagnosis predict 2-year outcome in sarcoidosis https://bit.ly/2JX8fhr ER -