@article {Lepzien2003468作者= {Rico Lepzien刘唱的和保罗Czarnewski和μ聂Bj {\“o rn} {\ " o} sterberg和Faezzah Baharom和Jamshid Pourazar和格里高利·兰金安德斯·埃克伦和Matteo Bottai苏珊娜Kullberg Blomberg安德斯和Johan Grunewald安娜Smed-S {\“o} rensen}, title ={单核细胞在结节病有效的肿瘤坏死因子生产者和预测疾病结果},体积= {58}= {1},elocation-id = {2003468} = {2021}, doi ={10.1183/13993003.03468 -2020},出版商={欧洲呼吸学会},文摘={背景肺结节病是一种炎症性疾病的特点是肉芽肿形成和异构的临床结果。188bet官网地址肿瘤坏死因子(TNF)是一种促炎细胞因子导致肉芽肿形成和高水平的肿瘤坏死因子已被证明与进步的疾病。单核吞噬细胞(基于)的有力生产商TNF和高度响应炎症。在结节病,肺泡巨噬细胞已经被充分研究过。然而,基于也包括单核细胞/ monocyte-derived细胞和树突细胞,在结节病研究甚少,尽管他们在炎症。目的确定肺monocyte-derived细胞和树突状细胞的作用在结节病。方法我们进行深入的表型、功能和转录组分析MNP子集的血液和支气管肺泡灌洗(BAL)流体从108年结节病患者和30名健康对照。我们跟着病人的临床开发和评估MNP子集的曲目和功能如何诊断与2年相关疾病的结果。单核细胞/ monocyte-derived细胞结果增加在血液和BAL结节病的患者与健康对照组相比。有趣的是,高频率的血液中间单核细胞时诊断与慢性疾病发展有关。核糖核酸测序分析显示高度炎症和基于BAL的结节病病人。此外,频率BAL单核细胞/ monocyte-derived细胞产生肿瘤坏死因子没有外源性刺激时诊断增加纵向随访的患者。 In contrast to alveolar macrophages, the frequency of TNF-producing BAL monocytes/monocyte-derived cells at time of diagnosis was highest in sarcoidosis patients that developed progressive disease.Conclusion Our data show that pulmonary monocytes/monocyte-derived cells are highly inflammatory and can be used as a predictor of disease outcome in sarcoidosis patients.Phenotypic, transcriptomic and functional mapping of blood and pulmonary mononuclear phagocytes in sarcoidosis patients found that frequency and function of pulmonary monocytes at time of diagnosis predict 2-year outcome in sarcoidosis https://bit.ly/2JX8fhr}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/1/2003468}, eprint = {//www.qdcxjkg.com/content/58/1/2003468.full.pdf}, journal = {European Respiratory Journal} }