% 0期刊文章%陈施一个秦魏% %选手张%一个沼泽盾%朱张% Bingzhu胡锦涛%紫阳李朱Fajiu % % Xiaojiang王%一个义民庙王%开元甄%王静%一个李张洪波YuLei Wan % %一个伊斯梅尔Elalamy % Chenghong李% Zhenguo翟%陈王% T扩散能力异常患者一氧化碳COVID-19 3个月随访2021% % D R 10.1183/13993003.03677 J欧洲呼吸杂志-2020% % P 2003677 X % V 58% N 1%客观评估肺功能和2019年冠状病毒病临床症状(COVID-19)幸存者出院后3个月内,和识别风险因素与肺功能受损有关。方法和材料COVID-19患者前瞻性随访的肺功能测试和临床特点3个月在武汉一家医院出院后,中国在2020年1月和2月之间。结果647例患者包括在内。87例(13%)患者出现疲软,63(10%)心悸和56(9%)和呼吸困难。的流行三种症状严重的患者明显高于长程患者(有下跌19%和10%,p = 0.003;心悸是14%比7%,p = 0.007;呼吸困难是12%比7%,p = 0.014)。多元回归结果显示增加的可能性持续症状严重的患者(或1.7,95%可信区间1.1 - -2.6;p = 0.026)或患者住院时间较长的(或1.03,95%可信区间1.00 - -1.05;p = 0.041)。肺功能测试结果可用于81名患者,包括41者和40严重的病人。在这个群,44例(54%)患者表现出异常的肺一氧化碳扩散能力(DLCO)(68%严重病人者42%,p = 0.019)。 Chest computed tomography (CT) total severity score >10.5 (OR 10.4, 95% CI 2.5–44.1; p=0.001) on admission and acute respiratory distress syndrome (ARDS) (OR 4.6, 95% CI 1.4–15.5; p=0.014) were significantly associated with impaired DLCO. Pulmonary interstitial damage may be associated with abnormal DLCO.Conclusion Pulmonary function, particularly DLCO, declined in COVID-19 survivors. This decrease was associated with total severity score of chest CT >10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied DLCO.COVID-19 patients present with impaired DLCO at 90 days after discharge, particularly severe patients. Chest CT TSS >10.5 and ARDS occurrence are associated with impaired DLCO. Pulmonary interstitial damage may contribute to the impaired DLCO. https://bit.ly/2JevUtm %U //www.qdcxjkg.com/content/erj/58/1/2003677.full.pdf