TY -的T1 -动力学SARS-CoV-2脱落的呼吸道取决于疾病的严重程度COVID-19病人摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.02724 -2020欧元六世- 58 - 1 SP - 2002724 AU -蒙克,迪盟-奥斯特曼Andreas盟——诊疗,汉斯AU - Muenchhoff,马克西米利安非盟- Veit,Tobias AU -温伯格,托拜厄斯盟——Barnikel,米凯拉盟——菊花,Jan-Niclas AU - Milger,凯特琳盟——Khatamzas Elham AU -克劳斯,莎拉盟,谢勒克莱门斯AU -赫尔穆特,约翰内斯·c . AU - Giessen-Jung克莱门斯盟,Zoller迈克尔盟——哈罗德,托拜厄斯盟——Stecher,斯蒂芬妮AU - de托尼,恩里科·n . AU -舒尔茨,基督教非盟- Kneidinger,尼古拉斯盟——开普勒,:奥利弗·t . AU - Behr Jurgen AU - Mayerle,茱莉亚盟-蒙克,Stefan Y1 - 2021/07/01 UR - //www.qdcxjkg.com/content/58/1/2002724.abstract N2 - COVID-19的一小部分患者发展为严重疾病表现和呼吸衰竭机械通气的必要性。确定风险患者对优化护理和早期治疗干预至关重要。我们研究了严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)的脱落动态与疾病严重程度的关系。我们分析了92例COVID-19患者的鼻咽部和气管脱落情况。入院时采集标准化的鼻咽拭子或痰标本。如果患者采用机械通气，则额外获得气管内抽吸样本。采用real-time PCR检测SARS-CoV-2 rna，量化病毒脱落。92例COVID-19患者中45%(41例)病程严重，需机械通气(重症组)。在第1周，从鼻咽拭子确定的初始病毒脱落在非重症和重症病例之间没有显著差异。在第2周，可以观察到严重疾病患者的病毒脱落仍然升高。 A time-course of C-reactive protein, interleukin-6 and procalcitonin revealed an even more protracted inflammatory response following the delayed drop of virus shedding load in severely ill patients. A significant proportion (47.8%) of patients showed evidence of prolonged viral shedding (>17 days), which was associated with severe disease courses (73.2%).We report that viral shedding does not differ significantly between severe and nonsevere COVID-19 cases upon admission to the hospital. Elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe disease course.This work finds that elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe COVID-19 disease course https://bit.ly/3p544zr ER -