RT期刊文章SR电子T1 SARS-CoV-2在呼吸道中的脱落动态取决于COVID-19患者的疾病严重程度JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 2002724 DO 10.1183/13993003.02724-2020 VO 58 IS 1 A1 Munker, Dieter A1 Osterman, Andreas A1 Stubbe, Hans A1 Muen188bet官网地址chhoff, Maximilian A1 Veit, Tobias A1 Weinberger, Tobias A1 Barnikel, Michaela A1 Mumm, Jan-Niclas A1 Milger, Katrin A1 Khatamzas, Elham A1 Klauss，Sarah A1 Scherer, Clemens A1 Hellmuth, Johannes C. A1 Giessen-Jung, Clemens A1 Zoller, Michael A1 Herold, Tobias A1 Stecher, Stephanie A1 de Toni, Enrico N. A1 Schulz, Christian A1 Kneidinger, Nikolaus A1 Keppler, Oliver T. A1 Behr, Jürgen A1 Mayerle, Julia A1 Munker, Stefan YR 2021 UL //www.qdcxjkg.com/content/58/1/2002724.abstract AB部分COVID-19患者进展为严重疾病表现，伴有呼吸衰竭和机械通气的必要性。识别有风险的患者对于优化护理和早期治疗干预至关重要。我们研究了严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)脱落与疾病严重程度的关系。我们分析了92例确诊COVID-19患者的SARS-CoV-2鼻咽和气管脱落情况。入院时，采集标准化的鼻咽拭子或痰样本。如果患者采用机械通气，则需额外获取气管内抽吸样本。采用SARS-CoV-2 rna实时荧光定量PCR检测病毒脱落量。92例患者中45%(41 / 92)病程严重，需机械通气(重症组)。第1周时，经鼻咽拭子测定的初始病毒脱落量在非重症病例与重症病例之间无明显差异。在第2周，可以观察到差异，因为重症患者的病毒脱落仍然升高。c反应蛋白、白细胞介素-6和降钙素原的时间过程显示，在重症患者病毒脱落负荷延迟下降后，炎症反应甚至更持久。 A significant proportion (47.8%) of patients showed evidence of prolonged viral shedding (>17 days), which was associated with severe disease courses (73.2%).We report that viral shedding does not differ significantly between severe and nonsevere COVID-19 cases upon admission to the hospital. Elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe disease course.This work finds that elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe COVID-19 disease course https://bit.ly/3p544zr