PT -期刊文章盟芒克迪盟-奥斯特曼Andreas盟——诊疗,汉斯AU - Muenchhoff,马克西米利安非盟- Veit Tobias AU -温伯格,托拜厄斯盟——Barnikel,米凯拉盟——菊花,Jan-Niclas AU - Milger,凯特琳盟——Khatamzas Elham AU -克劳斯,莎拉AU -谢勒,克莱门斯AU -赫尔穆特,约翰内斯·c . AU - Giessen-Jung克莱门斯盟,ZollerMichael AU - Herold, Tobias AU - Stecher, Stephanie AU - de Toni, Enrico N. AU - Schulz, Christian AU - Kneidinger, Nikolaus AU - Keppler, Oliver T. AU - Behr, Jürgen AU - Mayerle, Julia AU - Munker，Stefan TI -动力学SARS-CoV-2脱落的呼吸道取决于疾病的严重程度COVID-19患者援助- 10.1183/13993003.02724 -2020 DP - 2021年7月01 TA -欧洲呼吸杂志》第六PG - 2002724 - 58 IP - 1 4100 - 4099 - //www.qdcxjkg.com/content/58/1/2002724.short//www.qdcxjkg.com/content/58/1/2002724.full SO - Eur Respir J2021 7月01日;58 AB -部分COVID-19患者进展为严重的疾病表现，伴有呼吸衰竭，需要机械通气。确定风险患者对优化护理和早期治疗干预至关重要。我们研究了严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)的脱落动态与疾病严重程度的关系。我们分析了92例COVID-19患者的鼻咽部和气管脱落情况。入院时采集标准化的鼻咽拭子或痰标本。如果患者采用机械通气，则额外获得气管内抽吸样本。采用real-time PCR检测SARS-CoV-2 rna，量化病毒脱落。92例COVID-19患者中45%(41例)病程严重，需机械通气(重症组)。 At week 1, the initial viral shedding determined from nasopharyngeal swabs showed no significant difference between nonsevere and severe cases. At week 2, a difference could be observed as the viral shedding remained elevated in severely ill patients. A time-course of C-reactive protein, interleukin-6 and procalcitonin revealed an even more protracted inflammatory response following the delayed drop of virus shedding load in severely ill patients. A significant proportion (47.8%) of patients showed evidence of prolonged viral shedding (>17 days), which was associated with severe disease courses (73.2%).We report that viral shedding does not differ significantly between severe and nonsevere COVID-19 cases upon admission to the hospital. Elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe disease course.This work finds that elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe COVID-19 disease course https://bit.ly/3p544zr