@article {Munker2002724作者={芒克,迪特尔和奥斯特曼安德烈亚斯和诊疗,汉斯和Muenchhoff,马克西米利安和Veit,托拜厄斯温伯格,托拜厄斯和Barnikel,米凯拉和菊花,Jan-Niclas Milger,凯特琳和Khatamzas Elham克劳斯,萨拉和谢勒,克莱门斯和赫尔穆特,约翰内斯·c·Giessen-Jung,克莱门斯和Zoller,迈克尔和哈罗德,托拜厄斯和Stecher,斯蒂芬妮和托尼,恩里科·n·舒尔茨,基督教和Kneidinger,尼古拉斯和开普勒,:奥利弗·t·原意,J {\ " u} rgen Mayerle,茱莉亚和芒克,Stefan} title ={动力学SARS-CoV-2脱落的呼吸道取决于疾病的严重程度COVID-19病人},体积= {58}= {1},elocation-id = {2002724} = {2021}, doi ={10.1183/13993003.02724 -2020},出版商={欧洲呼吸学会},文摘= {COVID-19的一小部分病人发展为严重疾病表现和呼吸衰竭机械通气的必要性。188bet官网地址识别风险是至关重要的优化护理和患者早期治疗干预措施。我们调查的动力严重急性呼吸系统综合症冠状病毒2 (SARS-CoV-2)脱落相对于疾病严重程度。我们分析了92例鼻咽和气管脱落SARS-CoV-2 COVID-19诊断。在承认,标准化的鼻咽拭子或痰样本收集。如果患者机械通气,气管吸入样本另外。病毒传染被量化实时PCR检测SARS-CoV-2 RNA.45 \ % (41 92) COVID-19病人有严重的疾病与需要机械通气(集团)严重。在星期1,最初的病毒传染鼻咽拭子决定显示者和严重病例之间没有显著差异。在星期2,可以观察到不同病毒传染仍然高企的重症患者。时间进程的c反应蛋白、白细胞介素- 6和原降钙素显示一个更长期的炎症反应延迟下降后病毒负荷在重症患者。很大一部分(47.8 \ %)的患者显示病毒长时间脱落的证据(\ > 17天),这是与严重疾病相关课程(73.2 \ %)。我们报告,病毒传染不严重和COVID-19者之间的显著差异情况下住进医院时。 Elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe disease course.This work finds that elevated SARS-CoV-2 shedding in the second week of hospitalisation, a systemic inflammatory reaction peaking between the second and third week, and prolonged viral shedding are associated with a more severe COVID-19 disease course https://bit.ly/3p544zr}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/58/1/2002724}, eprint = {//www.qdcxjkg.com/content/58/1/2002724.full.pdf}, journal = {European Respiratory Journal} }