AU - Evangelopoulos, Dimitris AU - Chatzidiakou, Lia AU - Walton, Heather AU - Katsouyanni, Klea AU - Kelly, Frank J. AU - Quint, Jennifer K. AU - Jones, Roderic L. AU - Barratt，本杰明TI -个人暴露于空气污染和慢性阻塞性肺病患者的呼吸健康援助- 10.1183/13993003.03432 -2020 DP - 2021年在伦敦7月01 TA -欧洲呼吸杂志》第六PG - 2003432 - 58 IP - 1 4099 - //www.qdcxjkg.com/content/58/1/2003432.short 4100 - //www.qdcxjkg.com/content/58/1/2003432.full和欧元J2021 7月01;58 AB -以前的研究已经调查了空气污染对慢性阻塞性肺疾病(COPD)患者的影响，使用固定地点测量或有限数量的个人测量，通常是针对一种污染物和短时间内。这些限制可能会造成偏见并歪曲流行病学的联系，因为它们没有考虑到所有潜在的污染源或污染的时间变异性。我们使用在精细时空尺度上测量的个人暴露于各种污染物的详细信息，以获得更可靠的效果估计。研究人员对115名患者进行了平均连续128天的随访，他们携带了专门为该项目设计的个人监测仪，测量温度、二氧化氮(NO2)、臭氧(O3)、一氧化氮(NO)、一氧化碳(CO)、空气动力学直径<2.5和<10 μm的颗粒物，时间分辨率为1分钟。每位患者记录每日呼吸症状信息并测量呼气峰值流量(PEF)。一位肺科医生结合相关数据定义了一个表示“加重”的二元变量。使用混合效应模型评估暴露-反应相关性。We found that gaseous pollutants were associated with a deterioration in patients’ health. We observed an increase of 16.4% (95% CI 8.6–24.6%), 9.4% (95% CI 5.4–13.6%) and 7.6% (95% CI 3.0–12.4%) in the odds of exacerbation for an interquartile range increase in NO2, NO and CO, respectively. Similar results were obtained for cough and sputum. O3 was found to have adverse associations with PEF and breathlessness. No association was observed between particulate matter and any outcome.Our findings suggest that, when considering total personal exposure to air pollutants, mainly the gaseous pollutants affect COPD patients’ health.Significant adverse associations were found between the respiratory health of COPD patients and their personal exposure to gaseous pollutants measured using portable sensors over 6 months. No significant associations were found for particulate pollutants. https://bit.ly/3aqMT6O